Improving the accuracy of cardiac PET with motion-free imaging.

通过无运动成像提高心脏 PET 的准确性。

• 批准号: 436149-2013
• 负责人: Klein, Ran
• 金额: $ 2.33万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Group
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=596865
• 关键词: Improving; accuracy; cardiac; PET; motion

Cardiac positron emission tomography (PET) uses a minute amount of radioactive labelled compound, called a tracer, to image the heart. Dynamic PET uses a specialized scanner to image the patient over several minutes, taking a series of snap shots of the injected tracer as it distributes through the patient's body. The dynamic images can then be processed by specialized software to measure the rates at which the tracer interacts with the tissues in the body. These rates can be used to assess physiologic function. In cardiac PET we use these methods to measure functions such as myocardial (heart muscle) blood flow (MBF), which can be used to detect reduced blood supply to the heart. PET MBF measurement is a leading tool in basic research for understanding disease and measuring therapy effectiveness, and is emerging as an important clinical tool.

心脏正电子发射断层扫描 (PET) 使用微量的放射性标记化合物（称为示踪剂）对心脏进行成像。动态 PET 使用专门的扫描仪在几分钟内对患者进行成像，当注射的示踪剂在患者体内分布时拍摄一系列快照。然后可以通过专门的软件处理动态图像，以测量示踪剂与体内组织相互作用的速率。这些比率可用于评估生理功能。在心脏 PET 中，我们使用这些方法来测量心肌（心肌）血流量 (MBF) 等功能，可用于检测心脏供血减少情况。 PET MBF 测量是了解疾病和测量治疗效果的基础研究的领先工具，并且正在成为一种重要的临床工具。