Defining the molecular basis of chemoradiation sensitivity in HPV+ head and neck cancers.

定义 HPV 头颈癌放化疗敏感性的分子基础。

• 批准号: 358025
• 负责人: Fradet-Turcotte Amlie
• 金额: $ 50.71万
• 依托单位: Universit Laval
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2021-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=358025&lang=en
• 关键词: Crispr/Cas9; Dna Double-Strand Break Signalling; Dna Repair; Genomic Instability; Head And Neck Cancer; Human Papillomavirus; Oropharyngeal Cancer; Response To Chemoradiation; Viral Genome Integration; Viral Oncogene

Human papillomaviruses (HPV) infect undifferentiated stem cells of our skin. While our immune system clears most of these infections, the persistence of HPV can lead to the development of cervical cancer as well as head and neck cancer such as oropharynge

人类乳头瘤病毒(HPV)感染我们皮肤的未分化干细胞。虽然我们的免疫系统清除了这些感染中的大部分，但HPV的持续感染可能会导致宫颈癌以及头颈癌(如口咽癌)的发展。