Radionuclide-based bioorthogonal click chemistry for targeted molecular imaging and therapy

基于放射性核素的生物正交点击化学用于靶向分子成像和治疗

• 批准号: RGPIN-2014-04318
• 负责人: Wuest, Frank
• 金额: $ 2.48万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=610961
• 关键词: Radionuclide; based; bioorthogonal; click; chemistry

Cancer is a major public health problem. Currently, one in four deaths in the United States and Canada is due to cancer. Modern bioorganic and medicinal chemistry concepts aim at the development of novel tool to detect and treat cancer more efficiently. The proposed research project deals with the development of novel radiochemistry concepts and the design and synthesis of novel radiolabeled compounds to fulfill the promise of molecular imaging and targeted radiotherapy to improve patient care. The project will explore so-called click chemistry as highly innovative chemistry tool for the development of radiolabeled compounds for applications in medical research and mediacal practice. The term click chemistry defines a powerful set of chemical reactions to create heteroatom C-X-C links enabling the rapid, selective and high-yielding labeling of biomolecules. The proposed research project has the potential to open new avenues for improved diagnosis and therapy of human diseases, and to support the process of drug development. The project represents an innovative platform for the development and application of novel radiopharmaceuticals to enhance patient care.

癌症是一个重大的公共卫生问题。目前，在美国和加拿大，四分之一的死亡是由于癌症。现代生物有机和药物化学概念旨在开发新的工具，以更有效地检测和治疗癌症。拟议的研究项目涉及新型放射化学概念的发展以及新型放射性标记化合物的设计和合成，以实现分子成像和靶向放射治疗的承诺，以改善患者护理。该项目将探索所谓的点击化学作为高度创新的化学工具，用于开发放射性标记化合物，用于医学研究和医疗实践。术语点击化学定义了一组强大的化学反应，以产生杂原子C-X-C连接，从而能够快速，选择性和高产率地标记生物分子。拟议的研究项目有可能为改善人类疾病的诊断和治疗开辟新的途径，并支持药物开发过程。该项目代表了一个创新平台，用于开发和应用新型放射性药物，以加强患者护理。