Targeting mitochondrial protein folding in the inter-membrane space as a novel therapeutic strategy for AML

靶向膜间空间中的线粒体蛋白折叠作为 AML 的新型治疗策略

• 批准号: 354325
• 负责人: Schimmer Aaron D
• 金额: $ 52.94万
• 依托单位: University Health Network (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2021-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=354325&lang=en
• 关键词: Leukemia; Mitochondria; Stem Cells; Translational Research; Xenografts

The mitochondria are the energy producing factories in the cell. Most of the proteins in the mitochondria are made in the cytoplasm and transported into the mitochondria through the mitochondrial protein import pathway. In our preliminary data, we demon

线粒体是细胞中产生能量的工厂。线粒体中的蛋白质大部分在细胞质中产生，并通过线粒体蛋白质输入途径转运到线粒体中。在我们的初步数据中，我们是恶魔