From water-breathing nymphs to air-breathing adults: Insects as a model system to investigate the physiological challenges associated with the transition of life from water to land
从呼吸水的若虫到呼吸空气的成虫:昆虫作为模型系统来研究与生命从水到陆地的转变相关的生理挑战
基本信息
- 批准号:RGPIN-2014-05794
- 负责人:
- 金额:$ 2.84万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2016
- 资助国家:加拿大
- 起止时间:2016-01-01 至 2017-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This Discovery Program will take the novel approach of using aquatic insects to examine the physiological challenges associated with the transition from breathing water to breathing air. Aquatic insects support valuable freshwater ecosystems and fisheries, but are highly susceptible to changes in water quality, so understanding their physiology is of crucial importance for successful environmental management. Our current understanding of the respiratory challenges associated with moving between water and air comes from studying how aquatic animals, particularly vertebrates, have adapted their morphology and physiology to function on land. From this perspective, water-breathing is the ancestral condition and air-breathing is a derived state. The insects, however, have performed this feat in reverse, adapting their terrestrial air-breathing physiology to function in water. Although all adult insects are air-breathers, representatives of nine insect orders have evolved to be developmentally amphibious, spending the juvenile proportion of their life cycle as aquatic nymphs or larvae that possess gills and breathe water. These insect groups provide an exceptional opportunity to examine the evolution of adaptations associated with aquatic respiration, and to determine whether environmental constraints have caused gill-bearing insects to converge on a respiratory physiology comparable to other aquatic animals, or whether the phylogenetic constraints of their terrestrial ancestry have resulted in a respiratory physiology similar to air-breathing animals. The physiological consequences of the insects’ return to water are not well understood, but there is tantalizing evidence that water-breathing nymphs possess elevated internal CO2 levels commonly associated with breathing air, an observation that cannot be explained by current textbook dogma. Furthermore, we know nothing of the mechanisms and physiological shifts that enable these insects, during metamorphosis, to change rapidly from breathing with gills to using an air-filled respiratory system. My research program aims to identify and compare the respiratory and acid-base strategies used by water-breathing juvenile insects with those of the air-breathing adults, and to explore the physiological changes that occur during their rapid transition from water to land. I will use a range of techniques, including respirometry, morphometry and histology, to reveal the different strategies used by the aquatic and terrestrial life stages to regulate their internal oxygen and carbon dioxide levels, and their acid-base balance. Thus, this research program addresses a fundamental gap in our understanding of insect physiology and provides insight into the evolution of respiratory adaptations underlying the transition from water to land.
这个探索计划将采用一种新的方法,利用水生昆虫来研究从呼吸水到呼吸空气的转变过程中的生理挑战。水生昆虫支持有价值的淡水生态系统和渔业,但对水质变化高度敏感,因此了解它们的生理对于成功的环境管理至关重要。我们目前对在水和空气之间移动相关的呼吸挑战的理解来自于对水生动物,特别是脊椎动物如何适应陆地上的形态和生理功能的研究。从这个角度来看,呼吸水是祖先的状态,呼吸空气是一种衍生状态。然而,昆虫却反过来完成了这一壮举,调整了它们在陆地上呼吸空气的生理学,以适应在水中的活动。虽然所有的成虫都是呼吸空气的,但9个昆虫目的代表已经进化为发育中的两栖昆虫,在其生命周期的幼体部分作为水生若虫或拥有鳃和呼吸水的幼虫度过。这些昆虫类群为研究与水生呼吸相关的适应进化提供了一个难得的机会,并确定环境限制是否导致有鳃的昆虫汇聚到与其他水生动物类似的呼吸生理学上,或者它们陆地祖先的系统发育限制是否导致了类似于呼吸空气的动物的呼吸生理学。昆虫回到水中的生理后果尚不清楚,但有诱人的证据表明,呼吸水的若虫体内二氧化碳水平较高,通常与呼吸空气有关,这一观察结果无法用当前教科书上的教条来解释。此外,我们对使这些昆虫在变态过程中迅速从用鳃呼吸转变为使用充满空气的呼吸系统的机制和生理变化一无所知。我的研究项目旨在识别并比较呼吸水的幼虫和呼吸空气的成虫使用的呼吸和酸碱策略,并探索它们从水到陆地快速过渡过程中发生的生理变化。我将使用一系列技术,包括呼吸测量、形态测量和组织学,来揭示水生和陆地生命阶段调节其内部氧气和二氧化碳水平以及酸碱平衡所使用的不同策略。因此,这项研究计划解决了我们对昆虫生理学理解的一个根本差距,并提供了对从水到陆地过渡过程中潜在的呼吸适应进化的洞察。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Matthews, Philip其他文献
Logic Minimization Techniques with Applications to Cryptology
- DOI:
10.1007/s00145-012-9124-7 - 发表时间:
2013-04-01 - 期刊:
- 影响因子:3
- 作者:
Boyar, Joan;Matthews, Philip;Peralta, Rene - 通讯作者:
Peralta, Rene
Matthews, Philip的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Matthews, Philip', 18)}}的其他基金
Gas exchange in water and air: Revealing fundamental mechanisms underlying the development and control of the insect respiratory system
水和空气中的气体交换:揭示昆虫呼吸系统发育和控制的基本机制
- 批准号:
RGPIN-2020-07089 - 财政年份:2022
- 资助金额:
$ 2.84万 - 项目类别:
Discovery Grants Program - Individual
Gas exchange in water and air: Revealing fundamental mechanisms underlying the development and control of the insect respiratory system
水和空气中的气体交换:揭示昆虫呼吸系统发育和控制的基本机制
- 批准号:
RGPAS-2020-00039 - 财政年份:2022
- 资助金额:
$ 2.84万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Gas exchange in water and air: Revealing fundamental mechanisms underlying the development and control of the insect respiratory system
水和空气中的气体交换:揭示昆虫呼吸系统发育和控制的基本机制
- 批准号:
RGPIN-2020-07089 - 财政年份:2021
- 资助金额:
$ 2.84万 - 项目类别:
Discovery Grants Program - Individual
Gas exchange in water and air: Revealing fundamental mechanisms underlying the development and control of the insect respiratory system
水和空气中的气体交换:揭示昆虫呼吸系统发育和控制的基本机制
- 批准号:
RGPAS-2020-00039 - 财政年份:2021
- 资助金额:
$ 2.84万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Gas exchange in water and air: Revealing fundamental mechanisms underlying the development and control of the insect respiratory system
水和空气中的气体交换:揭示昆虫呼吸系统发育和控制的基本机制
- 批准号:
RGPIN-2020-07089 - 财政年份:2020
- 资助金额:
$ 2.84万 - 项目类别:
Discovery Grants Program - Individual
Gas exchange in water and air: Revealing fundamental mechanisms underlying the development and control of the insect respiratory system
水和空气中的气体交换:揭示昆虫呼吸系统发育和控制的基本机制
- 批准号:
RGPAS-2020-00039 - 财政年份:2020
- 资助金额:
$ 2.84万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
From water-breathing nymphs to air-breathing adults: Insects as a model system to investigate the physiological challenges associated with the transition of life from water to land
从呼吸水的若虫到呼吸空气的成虫:昆虫作为模型系统来研究与生命从水到陆地的转变相关的生理挑战
- 批准号:
RGPIN-2014-05794 - 财政年份:2019
- 资助金额:
$ 2.84万 - 项目类别:
Discovery Grants Program - Individual
From water-breathing nymphs to air-breathing adults: Insects as a model system to investigate the physiological challenges associated with the transition of life from water to land
从呼吸水的若虫到呼吸空气的成虫:昆虫作为模型系统来研究与生命从水到陆地的转变相关的生理挑战
- 批准号:
RGPIN-2014-05794 - 财政年份:2018
- 资助金额:
$ 2.84万 - 项目类别:
Discovery Grants Program - Individual
From water-breathing nymphs to air-breathing adults: Insects as a model system to investigate the physiological challenges associated with the transition of life from water to land
从呼吸水的若虫到呼吸空气的成虫:昆虫作为模型系统来研究与生命从水到陆地的转变相关的生理挑战
- 批准号:
RGPIN-2014-05794 - 财政年份:2017
- 资助金额:
$ 2.84万 - 项目类别:
Discovery Grants Program - Individual
From water-breathing nymphs to air-breathing adults: Insects as a model system to investigate the physiological challenges associated with the transition of life from water to land
从呼吸水的若虫到呼吸空气的成虫:昆虫作为模型系统来研究与生命从水到陆地的转变相关的生理挑战
- 批准号:
462242-2014 - 财政年份:2016
- 资助金额:
$ 2.84万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
相似海外基金
Collaborative Research: Phenotypic and lineage diversification after key innovation(s): multiple evolutionary pathways to air-breathing in labyrinth fishes and their allies
合作研究:关键创新后的表型和谱系多样化:迷宫鱼及其盟友呼吸空气的多种进化途径
- 批准号:
2333683 - 财政年份:2024
- 资助金额:
$ 2.84万 - 项目类别:
Continuing Grant
Collaborative Research: Phenotypic and lineage diversification after key innovation(s): multiple evolutionary pathways to air-breathing in labyrinth fishes and their allies
合作研究:关键创新后的表型和谱系多样化:迷宫鱼及其盟友呼吸空气的多种进化途径
- 批准号:
2333684 - 财政年份:2024
- 资助金额:
$ 2.84万 - 项目类别:
Continuing Grant
Computational and neural signatures of interoceptive learning in anorexia nervosa
神经性厌食症内感受学习的计算和神经特征
- 批准号:
10824044 - 财政年份:2024
- 资助金额:
$ 2.84万 - 项目类别:
Unravelling the neural basis of breathing, respiratory depression, and analgesia by opioid drugs.
揭示阿片类药物呼吸、呼吸抑制和镇痛的神经基础。
- 批准号:
479039 - 财政年份:2023
- 资助金额:
$ 2.84万 - 项目类别:
Operating Grants
Using clinical polysomnography data and machine learning to determine minimum sensing requirements for pediatric sleep studies
使用临床多导睡眠图数据和机器学习来确定儿科睡眠研究的最低传感要求
- 批准号:
491364 - 财政年份:2023
- 资助金额:
$ 2.84万 - 项目类别:
Operating Grants
Electrochemically Generated Inhaled Nitric Oxide (iNO) delivery via High Flow Nasal Cannula (HFNC)
通过高流量鼻插管 (HFNC) 输送电化学产生的吸入一氧化氮 (iNO)
- 批准号:
10637303 - 财政年份:2023
- 资助金额:
$ 2.84万 - 项目类别:
Transcutaneous Phrenic Nerve Stimulation for Treating Opioid Overdose
经皮膈神经刺激治疗阿片类药物过量
- 批准号:
10681111 - 财政年份:2023
- 资助金额:
$ 2.84万 - 项目类别:
Is gestational sleep apnea a previously unrecognized cause of maternal immune activation that predisposes male offspring to disease-relevant neural dysfunction?
妊娠期睡眠呼吸暂停是否是一种以前未被认识到的母体免疫激活的原因,导致男性后代容易出现与疾病相关的神经功能障碍?
- 批准号:
10680972 - 财政年份:2023
- 资助金额:
$ 2.84万 - 项目类别:
Mechanical signaling through the nuclear membrane in lung alveolar health
通过核膜的机械信号传导影响肺泡健康
- 批准号:
10677169 - 财政年份:2023
- 资助金额:
$ 2.84万 - 项目类别:
Targeting breathing limitations to improve functional outcomes in HFpEF
针对呼吸限制以改善 HFpEF 的功能结果
- 批准号:
10663768 - 财政年份:2023
- 资助金额:
$ 2.84万 - 项目类别:














{{item.name}}会员




