Mechanisms of ERK-dependent tumor suppression

ERK依赖性肿瘤抑制机制

• 批准号: 355588
• 负责人: Ferbeyre Gerardo
• 金额: $ 50.99万
• 依托单位: Universit de Montral
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2021-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=355588&lang=en
• 关键词: Erk Kinases; N-End Rule Of Protein Degradation; Oncogene Induced Senescence; Oncogenic Ras; Pancreatic Cancer; Phosphatase Inhibitors; Ribosome Biogenesis; Rsl1d1; Tumor Suppressor; Ubr4

Cellular senescence is a stable cell cycle arrest triggered by stresses that can cause cancer. Some cancer causing genes can activate this program in normal cells. The prototype senescence inducer is oncogenic RAS, a gene that is mutated in 30% of human c

细胞衰老是一种稳定的细胞周期停滞，由可能导致癌症的压力引发。一些致癌基因可以在正常细胞中激活这个程序。原型衰老诱导物是致癌的RAS，一种在30%的人类癌细胞中发生突变的基因。