Elimination of senescent cells to treat estrogen-deprivation associated disorders

消除衰老细胞以治疗雌激素剥夺相关疾病

• 批准号: 468415
• 负责人: Ferbeyre Gerardo
• 金额: $ 69.66万
• 依托单位: Centre hospitalier de l'Universit de Montral (CHUM)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-09-01 至 2027-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=468415&lang=en
• 关键词: Cellular Senescence; Estrogens; Inflammation; Macrophages; Menopause; Micrornas; Senolytics

Postmenopausal syndrome caused by estrogen deprivation can manifest itself as symptoms that decrease women's quality of life but also lead to serious health complications such as osteoporosis, metabolic syndrome and cardiovascular diseases. Estrogen repla

由雌激素剥夺引起的绝经后综合症可以表现为降低妇女生活质量的症状，但也会导致严重的健康并发症，如骨质疏松症、代谢综合征和心血管疾病。雌激素repla