Targeting senescence cells in pancreatic cancer

针对胰腺癌中的衰老细胞

• 批准号: 364242
• 负责人: Ferbeyre Gerardo
• 金额: --
• 依托单位: Universit de Montral
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-02-01 至 2020-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=364242&lang=en
• 关键词: Bcl2; Chemotherapy; Inflammation; Nad; P21; Premalignant Lesions; Senescence

Cellular senescence is a programmed response to oncogenic stress that aims to halt the expansion of cells with malignant potential. Senescent cells secrete inflammatory mediators that in the short term contribute to stop the proliferation of pre-cancerous

细胞衰老是对致癌应激的程序性反应，其目的是阻止具有恶性潜能的细胞的扩张。衰老细胞分泌炎症介质，在短期内有助于阻止癌前病变的增殖。