Cellular and molecular mechanisms regulating the progression of atherosclerosis: exploiting macrophage reverse transendothelial migration as a therapeutic strategy

调节动脉粥样硬化进展的细胞和分子机制：利用巨噬细胞逆向跨内皮迁移作为治疗策略

• 批准号: 355119
• 负责人: Cybulsky Myron I
• 金额: $ 236.52万
• 依托单位: University Health Network (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2023-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=355119&lang=en
• 关键词: Atherosclerosis; Cell Migration; Dendritic Cells; Endothelial Cells; Inflammation; Intima; Macrophages; Monocytes; Signalling; Transgenic Mouse Models

Atherosclerosis is a chronic inflammatory disease of arteries and remains the principal cause of death in our society despite effective cholesterol-lowering therapies. Atherosclerosis develops silently for decades before causing heart attacks and strokes.

动脉粥样硬化是动脉的一种慢性炎症性疾病，尽管有有效的降胆固醇疗法，但它仍然是导致我们社会死亡的主要原因。动脉粥样硬化在引起心脏病发作和中风之前会悄无声息地发展几十年。