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Novel Approaches Directed to Prevention and Treatment of Huntington Disease

Novel Approaches Directed to Prevention and Treatment of Huntington Disease
预防和治疗亨廷顿病的新方法
批准号：
354737
负责人：
Hayden Michael R
金额：
$259.96万
依托单位：
BC Children's Hospital Research Institute
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2016
资助国家：
加拿大
项目状态：
已结题
起止时间：
2016-10-01 至 2023-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=354737&lang=en
关键词：
Animal Models Drug Deliveries System Excitotoxicity Gene Silencing Huntington Disease Novel Pathways Proteolysis

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中文摘要
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英文摘要
Huntington disease (HD) is an inherited brain disease that affects approximately 1 in 7300 people in the Western world. HD is caused by a mutation in one copy of the HTT gene, which produces a toxic mutant huntingtin (mHTT) protein. This mutant protein di
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Allele-specific lowering of mutant polyQ proteins as treatment for Huntington disease, spinocerebellar ataxia type 3 and spinocerebellar ataxia type 7
Canada Research Chair Tier 1
  • 批准号：
    315426
  • 项目类别：
  • 资助金额：
    $101.99万
  • 财政年份：
    2014
  • 负责人：
    Hayden Michael R
  • 依托单位：
    University of British Columbia
Novel approaches to modulate key targets in the pathogenesis of Huntington Disease
Novel approaches to modulate key targets in the pathogenesis of Huntington Disease