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Novel approaches to modulate key targets in the pathogenesis of Huntington Disease

Novel approaches to modulate key targets in the pathogenesis of Huntington Disease
调节亨廷顿病发病机制关键靶点的新方法
批准号：
253299
负责人：
Hayden Michael R
金额：
$59.21万
依托单位：
BC Children's Hospital Research Institute
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-03-01 至 2017-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=253299&lang=en
关键词：
Animal Models Excitotoxicity Gene Silencing Huntington Disease Proteolysis

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中文摘要
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英文摘要
Huntington disease (HD) is a progressive neurodegenerative disease with no way to alter the course of the illness. The underlying genetic defect is a trinucleotide expansion in the huntingtin (htt) gene. A promising therapeutic approach for HD is to selec
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Allele-specific lowering of mutant polyQ proteins as treatment for Huntington disease, spinocerebellar ataxia type 3 and spinocerebellar ataxia type 7
Novel Approaches Directed to Prevention and Treatment of Huntington Disease
Canada Research Chair Tier 1
  • 批准号：
    315426
  • 项目类别：
  • 资助金额：
    $101.99万
  • 财政年份：
    2014
  • 负责人：
    Hayden Michael R
  • 依托单位：
    University of British Columbia
Novel approaches to modulate key targets in the pathogenesis of Huntington Disease
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