Novel approaches to modulate key targets in the pathogenesis of Huntington Disease
调节亨廷顿病发病机制关键靶点的新方法
基本信息
- 批准号:253299
- 负责人:
- 金额:$ 59.21万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Operating Grants
- 财政年份:2012
- 资助国家:加拿大
- 起止时间:2012-03-01 至 2017-03-01
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Huntington disease (HD) is a progressive neurodegenerative disease with no way to alter the course of the illness. The underlying genetic defect is a trinucleotide expansion in the huntingtin (htt) gene. A promising therapeutic approach for HD is to selec
亨廷顿病(HD)是一种进行性神经退行性疾病,无法改变疾病的进程。潜在的遗传缺陷是亨廷顿蛋白(htt)基因中的三核苷酸扩增。HD的一种有希望的治疗方法是选择性地
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Hayden Michael R其他文献
Hayden Michael R的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Hayden Michael R', 18)}}的其他基金
Allele-specific lowering of mutant polyQ proteins as treatment for Huntington disease, spinocerebellar ataxia type 3 and spinocerebellar ataxia type 7
等位基因特异性降低突变 PolyQ 蛋白作为亨廷顿病、脊髓小脑共济失调 3 型和脊髓小脑共济失调 7 型的治疗
- 批准号:
373043 - 财政年份:2017
- 资助金额:
$ 59.21万 - 项目类别:
Operating Grants
Novel Approaches Directed to Prevention and Treatment of Huntington Disease
预防和治疗亨廷顿病的新方法
- 批准号:
354737 - 财政年份:2016
- 资助金额:
$ 59.21万 - 项目类别:
Operating Grants
Novel approaches to modulate key targets in the pathogenesis of Huntington Disease
调节亨廷顿病发病机制关键靶点的新方法
- 批准号:
268516 - 财政年份:2012
- 资助金额:
$ 59.21万 - 项目类别:
Operating Grants
microRNA regulation of ABCA1 and its impact on beta cell function
ABCA1 的 microRNA 调控及其对 β 细胞功能的影响
- 批准号:
252457 - 财政年份:2012
- 资助金额:
$ 59.21万 - 项目类别:
Operating Grants
Drug Safety and Effectiveness Network (DSEN) Pharmacogenomics of Adverse Events National Team(PREVENT)
药物安全性和有效性网络 (DSEN) 不良事件药物基因组学国家小组(预防)
- 批准号:
237872 - 财政年份:2011
- 资助金额:
$ 59.21万 - 项目类别:
Directed Grant
Regulation of Function and Activitiy of ABCA1
ABCA1 功能和活性的调节
- 批准号:
201829 - 财政年份:2010
- 资助金额:
$ 59.21万 - 项目类别:
Operating Grants
CIHR Team in Palmitoylation in Huntington Disease
CIHR 团队在亨廷顿病棕榈酰化方面的研究
- 批准号:
188121 - 财政年份:2009
- 资助金额:
$ 59.21万 - 项目类别:
Operating Grants
Palmitoylation in Huntington Disease (Palm HD)
亨廷顿病中的棕榈酰化 (Palm HD)
- 批准号:
174390 - 财政年份:2008
- 资助金额:
$ 59.21万 - 项目类别:
Operating Grants
Development of Clincial Standards of Care for Huntington Disease Intermediate Allele Predictive Test Results
亨廷顿病中间等位基因预测测试结果临床护理标准的制定
- 批准号:
172289 - 财政年份:2008
- 资助金额:
$ 59.21万 - 项目类别:
Operating Grants
相似海外基金
Determining the ultrastructural differences between dually and singly innervated dendritic spines and their changes following glutamate excitotoxicity using Cryo-Electron Tomography
使用冷冻电子断层扫描确定双重和单神经支配的树突棘之间的超微结构差异及其在谷氨酸兴奋性毒性后的变化
- 批准号:
10679214 - 财政年份:2023
- 资助金额:
$ 59.21万 - 项目类别:
RIPK3-dependent suppression of excitotoxicity during neuronal flavivirus infection
神经元黄病毒感染期间依赖 RIPK3 的兴奋性毒性抑制
- 批准号:
10742250 - 财政年份:2023
- 资助金额:
$ 59.21万 - 项目类别:
Glutamate excitotoxicity drives neurological death in leptomeningeal metastasis
谷氨酸兴奋毒性导致软脑膜转移神经死亡
- 批准号:
471420 - 财政年份:2022
- 资助金额:
$ 59.21万 - 项目类别:
Fellowship Programs
Slow-wave sleep enhancement in those at risk for Alzheimer's disease: Links with memory, excitotoxicity, and plasma A-beta
慢波睡眠可增强阿尔茨海默病风险人群:与记忆、兴奋性毒性和血浆 A-β 的联系
- 批准号:
10207060 - 财政年份:2021
- 资助金额:
$ 59.21万 - 项目类别:
Slow-wave sleep enhancement in those at risk for Alzheimer's disease: Links with memory, excitotoxicity, and plasma A-beta
慢波睡眠可增强阿尔茨海默病风险人群:与记忆、兴奋性毒性和血浆 A-β 的联系
- 批准号:
10602504 - 财政年份:2021
- 资助金额:
$ 59.21万 - 项目类别:
Slow-wave sleep enhancement in those at risk for Alzheimer's disease: Links with memory, excitotoxicity, and plasma A-beta
慢波睡眠可增强阿尔茨海默病风险人群:与记忆、兴奋性毒性和血浆 A-β 的联系
- 批准号:
10436846 - 财政年份:2021
- 资助金额:
$ 59.21万 - 项目类别:
Novel Pathways to Excitotoxicity in Multiple Sclerosis Caused by Inappropriate Intrusion of an Axonal Mitochondrial Anchor Syntaphilin into Dendrites
轴突线粒体锚亲合蛋白不适当侵入树突引起的多发性硬化症兴奋性毒性的新途径
- 批准号:
10219369 - 财政年份:2020
- 资助金额:
$ 59.21万 - 项目类别:
Manganese exposure susceptibility as a modifier of excitotoxicity in Alzheimer's Disease
锰暴露敏感性作为阿尔茨海默病兴奋性毒性的调节剂
- 批准号:
10514587 - 财政年份:2020
- 资助金额:
$ 59.21万 - 项目类别:
Manganese exposure susceptibility as a modifier of excitotoxicity in Alzheimer's Disease
锰暴露敏感性作为阿尔茨海默病兴奋性毒性的调节剂
- 批准号:
10292965 - 财政年份:2020
- 资助金额:
$ 59.21万 - 项目类别: