Writing out an electrochemical biosensor using a pencil graphite

使用铅笔石墨写出电化学生物传感器

• 批准号: RGPIN-2015-05074
• 负责人: Parameswaran, Meenakshinathan
• 金额: $ 3.42万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=613341
• 关键词: Writing; out; electrochemical; biosensor; using

Because the quality of global healthcare delivery is based upon diagnostic capacity, advances in miniaturization of engineering technologies is fueling the development of portable electronic diagnostic instruments. Where, once a stand-alone, well-equipped, central laboratory was required to perform all tests, now portable electronics go directly to patients, wherever they may be. The key component is developing engineering processes and procedures for creating low-cost, portable, and sensitive sensors.     Traditional methods of detecting biomolecules use ELISA techniques in conjunction with fluorescent detection. This approach does not lend itself to miniaturization and portability because of the optical and electrical-power requirements. The most promising avenue for developing portable, low-power detection is with advances in engineering related to electronic sensors that directly detect target biomolecules using electrochemical approaches. Developments in engineering micro-technology and the availability of ultra-low-power electronics make possible the next generation of electronic sensors for detecting biomolecules and disease markers.     Our proposal explores new engineering techniques and methods to activate carbon and graphite electrodes to enhance their electrochemical sensitivity. To create biomolecule sensitive electrodes, we will use an activation process using a programmed sequence electrical-signal to enhance the surface sensitivity of carbon and graphite. Further, the activation process will allow detection of disease-causing pathogens with excellent selectivity. We will explore other methods to enhance the sensitivity of the electrodes using simple material-coating techniques. These methods are applicable for electrochemical systems that will detect trace and volatile biomolecules. In order for these diagnostics and screening systems to be usable in remote and impoverished areas, the system must use low-cost electronics, and it must interface with already available mobile phones and tablets for its computing power and data processing capabilities.     The proposed research program will enable the engineering of applied systems and open avenues for fundamental discovery in molecular and material science associated with health. This research and development with a scientific and engineering approach to create effective sensors applicable in this area will enable innovative solutions as well as technological and training opportunities for Canadian students and researchers. The IP created by this research will result in Canadian high-tech spin-offs that can produce the next generation of point-of-care diagnostic instrumentation and life-saving technology. This research and development will contribute not only to Canada, but also to global causes and the welfare of all of humanity.

由于全球医疗服务的质量取决于诊断能力，因此工程技术小型化的进步正在推动便携式电子诊断仪器的发展。过去，需要一个独立的、设备齐全的中心实验室来进行所有的测试，现在便携式电子设备可以直接送到患者手中，无论他们身在何处。关键部分是开发工程流程和程序，以创建低成本，便携式和敏感的传感器。     检测生物分子的传统方法使用ELISA技术结合荧光检测。由于光和电功率的要求，这种方法不适合小型化和便携性。开发便携式低功耗检测的最有前途的途径是与电子传感器相关的工程进展，这些传感器使用电化学方法直接检测目标生物分子。工程微技术的发展和超低功耗电子器件的可用性使得下一代用于检测生物分子和疾病标志物的电子传感器成为可能。     我们的提案探索了新的工程技术和方法来活化碳和石墨电极，以提高其电化学灵敏度。为了制造生物分子敏感电极，我们将使用程序化序列电信号的活化过程来增强碳和石墨的表面灵敏度。此外，活化过程将允许以优异的选择性检测致病病原体。我们将探索其他方法来提高灵敏度的电极使用简单的材料涂层技术。这些方法适用于检测痕量和挥发性生物分子的电化学系统。为了使这些诊断和筛查系统能够在偏远和贫困地区使用，该系统必须使用低成本的电子产品，并且必须与现有的移动的电话和平板电脑连接，以获得其计算能力和数据处理能力。     拟议的研究计划将使应用系统的工程和开放的途径，在与健康相关的分子和材料科学的基础发现。这项研究和开发采用科学和工程方法，创造适用于该领域的有效传感器，将为加拿大学生和研究人员提供创新解决方案以及技术和培训机会。这项研究创造的知识产权将产生加拿大高科技副产品，可以生产下一代即时诊断仪器和救生技术。这项研究和发展不仅将有助于加拿大，而且也有助于全球事业和全人类的福祉。