Preparation, isolation, and characterization of fragile acid-base complexes including intermediates of potential biological relevance

脆弱酸碱复合物的制备、分离和表征，包括具有潜在生物相关性的中间体

• 批准号: RGPIN-2016-04204
• 负责人: Clyburne, Jason
• 金额: $ 2.62万
• 依托单位: Saint Mary's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=614912
• 关键词: Preparation; isolation; characterization; fragile; acid

The chemical behavior of small reactive gases such as carbon dioxide and the sulfur oxides is important on the large-scale vis-À-vis global warming and acid rain. Often overlooked is their role in materials and in biological systems. In order to understand more of this chemistry, we are systematically exploring the reactivity of these small gaseous molecules in a wide variety of environments, including unusual solvents and also within porous materials. This exploration can be guided by the use of coordination chemistry, a process wherein a small molecule or ion donates electrons to the reactive gas. When an interaction occurs a new bond is formed, which often results in significant modification of the behavior and reactivity of the parent gas. In the case of strong interactions, the product molecules can sequester the gas. In the case of weak interactions, the chemistry of the gaseous molecule may be altered but the gas can subsequently be released because it is only weakly held. In this proposal we outline our plan to explore the chemistry of carbon dioxide, carbon disulfide, sulfur dioxide and sulfur trioxide in a wide variety of chemical environments. As mentioned above, this chemistry will be important for our understanding of these industrial gases on a large-scale. The studies in new and unusual media will provide valuable insight as to how nature handles these important molecules within, for example, the active sites of enzymes, i.e., on a much smaller scale.

小的反应气体，如二氧化碳和硫氧化物的化学行为是重要的大尺度维斯维斯全球变暖和酸雨。经常被忽视的是它们在材料和生物系统中的作用。为了更多地了解这种化学，我们正在系统地探索这些小气体分子在各种环境中的反应性，包括不寻常的溶剂和多孔材料。这种探索可以通过使用配位化学来指导，配位化学是一种小分子或离子向反应气体提供电子的过程。当相互作用发生时，形成新的键，这通常导致母体气体的行为和反应性的显著改变。在强相互作用的情况下，产物分子可以隔离气体。在弱相互作用的情况下，气体分子的化学性质可能会改变，但气体随后可以释放，因为它只是被弱地保持。 在本提案中，我们概述了我们的计划，以探索二氧化碳，二硫化碳，二氧化硫和三氧化硫在各种化学环境中的化学。如上所述，这种化学对于我们大规模了解这些工业气体非常重要。在新的和不寻常的介质中的研究将提供有价值的见解，如自然如何处理这些重要的分子，例如，酶的活性位点，即，在一个小得多的规模上。