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Small molecules targeting aberrant STAT3 activity: killing breast tumour cells and inducing an anti-tumour immune response.

Small molecules targeting aberrant STAT3 activity: killing breast tumour cells and inducing an anti-tumour immune response.
针对异常 STAT3 活性的小分子:杀死乳腺肿瘤细胞并诱导抗肿瘤免疫反应。
批准号:
355181
负责人:
Gunning Patrick T
金额:
$56.84万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-10-01 至 2020-10-01

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英文摘要
Here, we describe a class of novel drug-like molecules that potently and selectively kill both Her2+ and triple negative breast cancer cells over normal healthy cells. These molecules target a protein called STAT3, that has been shown to play a key role i
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Development of Selective HDAC6 Small Molecule Inhibitors for the Treatment of Brain Cancers
  • 批准号:
    470153
  • 项目类别:
    Operating Grants
  • 资助金额:
    $49.32万
  • 财政年份:
    2022
  • 负责人:
    Gunning Patrick T
  • 依托单位:
Canada Research Chair - Tier 2 - CIHR Funded
  • 批准号:
    384907
  • 项目类别:
  • 资助金额:
    $36.43万
  • 财政年份:
    2017
  • 负责人:
    Gunning Patrick T
  • 依托单位:
Extending life in refractory medulloblastoma patients with cancer stem cell killing small molecules
Developing STAT5 protein inhibitors for treatment of Leukemia
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