Rheology Facility for Materials Characterization and Tissue Engineering

用于材料表征和组织工程的流变学设施

• 批准号: RTI-2017-00196
• 负责人: Bohne, Cornelia
• 金额: $ 10.86万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=616590
• 关键词: Rheology; Facility; Materials; Characterization; Tissue

The current proposal is for the acquisition of a versatile rheometer used for the characterization of the viscoelastic properties of materials and the monitoring of the integrity of materials during cell growth. The research programs span biomaterial-based tissue engineering (Akbari, Willerth), hard polymers (Wulff), soft self-assembled polymers (Moffitt), bioanalytics (Brolo) and supramolecular gels (Bohne). The proposed rheometer will be used with materials with very different elasticities. This equipment will be used to study the properties of tough organic polymers used in the automotive industry where the Wulff group was able to synthesize a functionalized version of an industrially important polymer material that overcame serious shortcomings of previous materials. At the other extreme of uses, the Akbari group will study the growth of cells in hydrogels while the cells are growing on the material in order to evaluate how degradation of the developed biomaterials can be minimized. Willerth will investigate biomaterial scaffolds that are combined with pluripotent stem cells. Brolo’s group is developing new hydrogels with embedded nanoparticles for real-time monitoring of surface contaminants in the natural environment. The rheometer will be used by the Moffitt group to optimize the photonic properties of self-assembled polymeric materials being developed. Bohne’s lab will investigate how small molecules move within hydrogels with the aim of understanding how this mobility can be used to time the release of small molecules from hydrogels; a process of importance in drug delivery.

目前的建议是收购一个多功能的流变仪用于表征材料的粘弹性和监测细胞生长过程中的材料的完整性。研究项目涵盖生物材料组织工程（Akbari，Willerth），硬聚合物（Wulff），软自组装聚合物（Moffitt），生物分析（Brolo）和超分子凝胶（Bohne）。 所提出的流变仪将用于具有非常不同的弹性的材料。该设备将用于研究汽车工业中使用的坚韧有机聚合物的特性，Wulff小组能够合成一种工业上重要的聚合物材料的功能化版本，克服了以前材料的严重缺点。在另一个极端的用途中，Akbari小组将研究细胞在水凝胶中的生长，同时细胞在材料上生长，以评估如何最大限度地减少开发的生物材料的降解。Willerth将研究与多能干细胞结合的生物材料支架。Brolo的团队正在开发嵌入纳米粒子的新型水凝胶，用于实时监测自然环境中的表面污染物。流变仪将被Moffitt小组用于优化正在开发的自组装聚合物材料的光子特性。Bohne的实验室将研究小分子如何在水凝胶中移动，目的是了解这种流动性如何用于确定小分子从水凝胶中释放的时间;这是药物输送的重要过程。