Rheology Facility for Materials Characterization and Tissue Engineering

用于材料表征和组织工程的流变学设施

• 批准号: RTI-2017-00196
• 负责人: Bohne, Cornelia
• 金额: $ 10.86万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=616590
• 关键词: Rheology; Facility; Materials; Characterization; Tissue

The current proposal is for the acquisition of a versatile rheometer used for the characterization of the viscoelastic properties of materials and the monitoring of the integrity of materials during cell growth. The research programs span biomaterial-based tissue engineering (Akbari, Willerth), hard polymers (Wulff), soft self-assembled polymers (Moffitt), bioanalytics (Brolo) and supramolecular gels (Bohne). The proposed rheometer will be used with materials with very different elasticities. This equipment will be used to study the properties of tough organic polymers used in the automotive industry where the Wulff group was able to synthesize a functionalized version of an industrially important polymer material that overcame serious shortcomings of previous materials. At the other extreme of uses, the Akbari group will study the growth of cells in hydrogels while the cells are growing on the material in order to evaluate how degradation of the developed biomaterials can be minimized. Willerth will investigate biomaterial scaffolds that are combined with pluripotent stem cells. Brolo’s group is developing new hydrogels with embedded nanoparticles for real-time monitoring of surface contaminants in the natural environment. The rheometer will be used by the Moffitt group to optimize the photonic properties of self-assembled polymeric materials being developed. Bohne’s lab will investigate how small molecules move within hydrogels with the aim of understanding how this mobility can be used to time the release of small molecules from hydrogels; a process of importance in drug delivery.

目前的建议是获得一种通用流变仪，用于表征材料的粘弹性特性和监测细胞生长过程中材料的完整性。研究项目涵盖基于生物材料的组织工程（Akbari, Willerth），硬聚合物（Wulff），软自组装聚合物（Moffitt），生物分析（Brolo）和超分子凝胶（Bohne）。