A transcranial magnetic stimulation setup for animal research
用于动物研究的经颅磁刺激装置
基本信息
- 批准号:RTI-2017-00580
- 负责人:
- 金额:$ 10.77万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Research Tools and Instruments
- 财政年份:2016
- 资助国家:加拿大
- 起止时间:2016-01-01 至 2017-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Non-invasive brain stimulation methods (NIBS) have transformed our capacity to study the brain. In particular, transcranial magnetic stimulation (TMS) techniques can be used to modulate neural activity of specific brain areas, allowing us to study how various brain areas interact and to probe their role in behavior. While these promising new techniques are widely used in humans, we have a poor understanding of their mechanisms of action because few laboratories have the ability to test them on animal models. Yet, there is an urgent need to compare the effects of TMS with those obtained using invasive methods.
At the Pavillon Desmarais of the Université de Montréal, we have a very strong group of systems scientists interested in studying the neural mechanisms underlying sensorimotor and decision-making behaviors. While we use invasive techniques (e.g. microstimulation, recording of neural activity, etc.) in our animal models, our questions are very close to those of many scientists using TMS in humans. We are thus in a strategic position to incorporate the use of TMS in our respective experiments and to combine it with our invasive methods. The results would fill major gaps in our fields of research and allow us to become leaders in using these combined approaches (TMS and invasive methods).
Consequently, this proposal requests funds to acquire a state-of-the-art TMS setup, adapted to our animal models. In particular, this equipment will allow us to conduct paired-pulse or ‘dual-site’ stimulation protocols to study questions related to cortical interactions for the control of hand movement (Dancause) and decision making (Cisek). In addition, the use of high-frequency repetitive TMS will allow us to modulate specific brain and spinal circuits in order to probe their contribution to decision-making (Cisek), reaching (Green) and locomotor (Martinez) behavior. This equipment, by complementing our current set of experiments, will rapidly expand our respective research programs. The data obtained with our TMS experiments will provide new knowledge that will directly impact the large community of systems scientists interested in the neural mechanisms underlying behavior, putting us at the forefront of our research fields. These experiments will additionally provide new insights into the mechanisms of action of TMS techniques, which are commonly used in human studies of motor control and decision-making.
非侵入性脑刺激方法(NIBS)改变了我们研究大脑的能力。特别是,经颅磁刺激(TMS)技术可以用来调节特定大脑区域的神经活动,使我们能够研究不同大脑区域如何相互作用,并探索它们在行为中的作用。虽然这些有前途的新技术被广泛应用于人类,但我们对它们的作用机制知之甚少,因为很少有实验室有能力在动物模型上进行测试。然而,迫切需要比较经颅磁刺激与侵入性方法的效果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Dancause, Numa其他文献
Parallel Cortical Networks Formed by Modular Organization of Primary Motor Cortex Outputs
- DOI:
10.1016/j.cub.2016.04.068 - 发表时间:
2016-07-11 - 期刊:
- 影响因子:9.2
- 作者:
Hamadjida, Adjia;Dea, Melvin;Dancause, Numa - 通讯作者:
Dancause, Numa
A stretch reflex in extraocular muscles of species purportedly lacking muscle spindles
- DOI:
10.1007/s00221-006-0833-8 - 发表时间:
2007-06-01 - 期刊:
- 影响因子:2
- 作者:
Dancause, Numa;Taylor, Michael D.;Feldman, Anatol G. - 通讯作者:
Feldman, Anatol G.
Corticospinal neurons in macaque ventral premotor cortex with mirror properties: a potential mechanism for action suppression?
- DOI:
10.1016/j.neuron.2009.12.010 - 发表时间:
2009-12-24 - 期刊:
- 影响因子:16.2
- 作者:
Kraskov, Alexander;Dancause, Numa;Quallo, Marsha M.;Shepherd, Samantha;Lemon, Roger N. - 通讯作者:
Lemon, Roger N.
Contrasting Modulatory Effects from the Dorsal and Ventral Premotor Cortex on Primary Motor Cortex Outputs
- DOI:
10.1523/jneurosci.0462-17.2017 - 发表时间:
2017-06-14 - 期刊:
- 影响因子:5.3
- 作者:
Cote, Sandrine L.;Hamadjida, Adjia;Dancause, Numa - 通讯作者:
Dancause, Numa
A translational roadmap for transcranial magnetic and direct current stimulation in stroke rehabilitation: Consensus-based core recommendations from the third stroke recovery and rehabilitation roundtable.
- DOI:
10.1177/17474930231203982 - 发表时间:
2024-02 - 期刊:
- 影响因子:6.7
- 作者:
Edwards, Jodi D.;Dominguez-Vargas, Adan Ulises;Rosso, Charlotte;Branscheidt, Meret;Sheehy, Lisa;Quandt, Fanny;Zamora, Simon A.;Fleming, Melanie K.;Azzollini, Valentina;Mooney, Ronan A.;Stagg, Charlotte J.;Gerloff, Chiristian;Rossi, Simone;Cohen, Leonardo G.;Celnik, Pablo;Nitsche, Michael A.;Buetefisch, Cathrin M.;Dancause, Numa - 通讯作者:
Dancause, Numa
Dancause, Numa的其他文献
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{{ truncateString('Dancause, Numa', 18)}}的其他基金
Cortical interactions involved in the production of hand movements
参与手部动作产生的皮质相互作用
- 批准号:
RGPIN-2022-04210 - 财政年份:2022
- 资助金额:
$ 10.77万 - 项目类别:
Discovery Grants Program - Individual
The effect of cortical interactions on motor output by the primary motor cortex
皮质相互作用对初级运动皮层运动输出的影响
- 批准号:
RGPIN-2016-05718 - 财政年份:2021
- 资助金额:
$ 10.77万 - 项目类别:
Discovery Grants Program - Individual
The effect of cortical interactions on motor output by the primary motor cortex
皮质相互作用对初级运动皮层运动输出的影响
- 批准号:
RGPIN-2016-05718 - 财政年份:2020
- 资助金额:
$ 10.77万 - 项目类别:
Discovery Grants Program - Individual
The effect of cortical interactions on motor output by the primary motor cortex
皮质相互作用对初级运动皮层运动输出的影响
- 批准号:
RGPIN-2016-05718 - 财政年份:2019
- 资助金额:
$ 10.77万 - 项目类别:
Discovery Grants Program - Individual
The effect of cortical interactions on motor output by the primary motor cortex
皮质相互作用对初级运动皮层运动输出的影响
- 批准号:
RGPIN-2016-05718 - 财政年份:2018
- 资助金额:
$ 10.77万 - 项目类别:
Discovery Grants Program - Individual
The effect of cortical interactions on motor output by the primary motor cortex
皮质相互作用对初级运动皮层运动输出的影响
- 批准号:
492905-2016 - 财政年份:2018
- 资助金额:
$ 10.77万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
The effect of cortical interactions on motor output by the primary motor cortex
皮质相互作用对初级运动皮层运动输出的影响
- 批准号:
492905-2016 - 财政年份:2017
- 资助金额:
$ 10.77万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
The effect of cortical interactions on motor output by the primary motor cortex
皮质相互作用对初级运动皮层运动输出的影响
- 批准号:
RGPIN-2016-05718 - 财政年份:2017
- 资助金额:
$ 10.77万 - 项目类别:
Discovery Grants Program - Individual
The effect of cortical interactions on motor output by the primary motor cortex
皮质相互作用对初级运动皮层运动输出的影响
- 批准号:
492905-2016 - 财政年份:2016
- 资助金额:
$ 10.77万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
The effect of cortical interactions on motor output by the primary motor cortex
皮质相互作用对初级运动皮层运动输出的影响
- 批准号:
RGPIN-2016-05718 - 财政年份:2016
- 资助金额:
$ 10.77万 - 项目类别:
Discovery Grants Program - Individual
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