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Understanding host-pathogen interactions between Atlantic salmon and saprolegnia parasitica in order to develop new approaches for disease management

Understanding host-pathogen interactions between Atlantic salmon and saprolegnia parasitica in order to develop new approaches for disease management
了解大西洋鲑鱼和寄生水霉之间的宿主-病原体相互作用,以开发疾病管理的新方法
批准号:
468322-2014
负责人:
Hintz, William
金额:
$4.59万
依托单位:
依托单位国家:
加拿大
项目类别:
Collaborative Research and Development Grants
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-12-31

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中文摘要
翻译
全球鱼类产量的增长几乎完全是由于水产养殖增加了鳍鱼产量,占2011年供人类消费的鱼类总产量的41%以上(6360万吨)(粮农组织,2012年)。水产养殖经济损失的最大原因是鱼类疾病,卵菌感染的影响仅次于细菌感染。腐生菌属的卵菌可引起腐生菌病。加拿大水产养殖业广泛认识到,这种疾病在所有淡水作业中普遍存在,由于它对鱼类健康的影响,对鱼类生产造成了额外的成本。本研究的中心科学目标是开发实验工具并建立一个信息数据库,以便我们更好地了解大西洋鲑鱼宿主物种与病原菌之间的宿主-病原体相互作用。对感染过程和宿主反应的更好理解将使我们能够确定每个过程的特定元素,这些元素可能作为疾病抑制和控制的潜在基因靶点。这些目标将在随后的研究中进行检查,重点是控制坏血病的措施。对病原体感染机制的进一步了解,以及对宿主如何作出反应的更好了解,将为水产养殖业的疾病管理提供有价值的信息。
英文摘要
Growth in global fish production is due almost entirely to the increase in fin fish production by aquaculture, representing more than 41% (63.6 million tonnes) of total fish production for human consumption in 2011 (FAO, 2012). The largest cause of economic losses in aquaculture is from fish diseases, with oomycete infections being second only to bacterial infections in terms of their impact. Oomycetes of the genus Saprolegnia can cause saprolegniosis. It is widely recognized by the aquaculture industry in Canada that this disease is prevalent in all freshwater operations and represents an additional cost to fish production due to its impact on fish health. The central scientific objective of this study is to develop experimental tools and generate an information database from which we can attain a better understanding of host-pathogen interactions between the host species of Atlantic salmon and the pathogen Saprolegnia parasitica. An improved understanding of both the infection process and host response will allow us to identify specific elements of each process that may serve as potential gene targets for disease suppression and control. These targets will be examined in subsequent studies focused on control measures for Saprolegniosis. An improved understanding of the infection mechanisms followed by the pathogen, as well as a better understanding of how the host does respond will provide valuable information for disease management by the aquaculture industry.
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  • 项目类别:
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  • 资助金额:
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  • 负责人:
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  • 依托单位:
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  • 批准号:
    138387-2013
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.82万
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  • 批准号:
    468322-2014
  • 项目类别:
    Collaborative Research and Development Grants
  • 资助金额:
    $4.59万
  • 财政年份:
    2016
  • 负责人:
    Hintz, William
  • 依托单位:
The use of transmissible hypovirulence for the biological control of Ophiostoma, the causal agent of Dutch elm disease
  • 批准号:
    138387-2013
  • 项目类别:
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  • 资助金额:
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