Non-diffusing 3D gel dosimeters: A platform technology for dose verification and quality assurance in radiation therapy

非扩散 3D 凝胶剂量计：放射治疗剂量验证和质量保证的平台技术

• 批准号: 493723-2016
• 负责人: Mequanint, Kibret
• 金额: $ 10.61万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=621874
• 关键词: Non; diffusing; 3D; gel; dosimeters

Radiation therapy, which destroys cancer cells and shrinks tumors in a target area, is a routine clinical practice. Traditionally,radiation treatments have been carried out in two dimensions (i.e. width and height). Rapid advances in solid tumor imagingtechniques such as computed tomography (CT) and magnetic resonance imaging (MRI), however, allowed the use of threedimension(3D; width, height, and depth) radiation therapy where more precise targeting of a target tumor with radiationsources is possible. Despite the advances made to locate the tumor and to deliver therapeutic radiation in 3D target volumewith high conformity and precision, measurement of 3D dose distribution has not been matched. The goal of this CHRPproposal is to design radiation dose measuring kits (dosimeters) from naturally occurring hydrogel and synthetic materials forpredictable treatment outcome.

放射治疗是一种常规的临床实践，它可以摧毁癌细胞并缩小目标区域的肿瘤。传统上，放射治疗是在两个维度（即宽度和高度）上进行的。然而，实体瘤成像技术的快速发展，如计算机断层扫描（CT）和磁共振成像（MRI），允许使用三维（3D;宽度，高度和深度）放射治疗，其中可以使用放射源更精确地靶向靶肿瘤。尽管在定位肿瘤和以高一致性和精确性在3D靶体积中提供治疗辐射方面取得了进展，但3D剂量分布的测量尚未匹配。该CHRP提案的目标是设计辐射剂量测量套件（剂量计），采用天然水凝胶和合成材料，以获得可预测的治疗结果。