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Magnetic Tweezer Force Spectroscopy for Mechanotransduction Studies

用于机械传导研究的磁镊力谱

基本信息

批准号：
RTI-2020-00288
负责人：
Mequanint, Kibret
金额：
$ 10.93万
依托单位：
University of Western Ontario
依托单位国家：
加拿大
项目类别：
Research Tools and Instruments
财政年份：
2019
资助国家：
加拿大
起止时间：
2019-01-01 至 2020-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693785
关键词：
Magnetic Tweezer Force Spectroscopy Mechanotransduction

项目摘要

The nature of the work to be done: Cardiovascular disease such as coronary artery occlusion is one of the leading causes of death in Canada. For patients with severe coronary artery blockage, catheter-based interventions such as coronary angioplasty and stenting are frequently utilized. However, angioplasty and stenting are limited by the undesired and uncontrolled proliferation of smooth muscle cells that eventually reocclude the artery. Through the ongoing NSERC DG and DAS funding, the research program will focus on developing novel enabling technologies to address the challenges associated with stenting by functional conjugation of Jagged1 Notch ligand to stents with the aim of improving vascular reparative outcome. This RTI funding request is to purchase a critically needed magnetic tweezer force spectroscopy for the research program.******Why and to whom the research is important and the anticipated outcomes: The proposed research is important because it brings together biomaterials and biology to heart disease. The proposed research will provide fundamental understandings about one of the unsolved challenges in stent performance. The applicant anticipates to develop stents with conjugated Jagged1 that arrests the undesired smooth muscle cell proliferation that leads to reocclusion. In the process, gaining fundamental materials-induced cell biology knowledge is also anticipated. ******The benefits to the research field and to Canada: The proposed research utilizes one type of biomaterials (stents) to present Jagged1 to cells. The proposed research will result in significant technology development for applications in future human health and economic benefit to Canada by opening up new markets in the medical stent and biomaterials-based therapeutic technology sector.**

工作性质：冠状动脉阻塞等心血管疾病是加拿大的主要死因之一。对于患有严重冠状动脉阻塞的患者，经常使用基于导管的介入治疗，例如冠状动脉血管成形术和支架植入术。然而，血管成形术和支架植入术受到平滑肌细胞的不期望的和不受控制的增殖的限制，平滑肌细胞的增殖最终使动脉再闭塞。通过正在进行的NSERC DG和DAS资助，该研究计划将专注于开发新的使能技术，通过将Jagged1 Notch配体功能性结合到支架上来解决与支架相关的挑战，旨在改善血管修复结果。RTI的资金申请是为研究项目购买急需的磁镊子力谱仪。**为什么和谁的研究是重要的和预期的结果：拟议的研究是重要的，因为它汇集了生物材料和生物学心脏病。拟议的研究将提供关于支架性能中未解决的挑战之一的基本理解。申请人预期开发具有缀合的锯齿状蛋白1的支架，其阻止导致再闭塞的不期望的平滑肌细胞增殖。在这个过程中，获得基本的材料诱导的细胞生物学知识也是预期的。** 对研究领域和加拿大的好处：拟议的研究利用一种生物材料（支架）将Jagged1呈现给细胞。拟议的研究将通过在医用支架和基于生物材料的治疗技术领域开辟新市场，为加拿大未来的人类健康和经济利益的应用带来重大的技术发展。