Australian Advanced Metabolic Signal Discovery, and Imaging Platform

澳大利亚先进代谢信号发现和成像平台

• 批准号: LE240100068
• 负责人: Dr Ryan McQuinn
• 金额: $ 62.14万
• 依托单位: Western Sydney University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE240100068
• 关键词: Australian; Advanced; Metabolic; Signal; Discovery

This proposal aims to establish an Australian Advanced Metabolic Signal Discovery and Imaging platform. The platform consists of an ultra-high resolution gas chromatography mass spectrometer and an imaging mass spectrometry upgrade for a second existing high resolution mass spectrometer. The facility will break barriers currently limiting discovery and localisation of metabolic changes during plant and animal development under environmental stress; integral chemical signals exchanged in host-microbe interactions; and volatile signatures linked to ecosystem health and developmental anomalies in animals. Results will inform innovative strategies to enhance biological adaptation, climate resilience and plant, animal, and ecosystem health.

该提案旨在建立澳大利亚先进代谢信号发现和成像平台。该平台由超高分辨率气相色谱质谱仪和第二台现有高分辨率质谱仪的成像质谱升级版组成。该设施将打破目前限制环境压力下植物和动物发育过程中代谢变化的发现和定位的障碍；宿主-微生物相互作用中交换的完整化学信号；以及与生态系统健康和动物发育异常相关的不稳定特征。结果将为增强生物适应、气候适应能力以及植物、动物和生态系统健康的创新战略提供信息。