NSERC CREATE in Biological information processing: From genome to systems level

NSERC CREATE 生物信息处理：从基因组到系统水平

• 批准号: 414018-2012
• 负责人: Sutherland, Robert
• 金额: $ 21.86万
• 依托单位: University of Lethbridge
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Training Experience
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628778
• 关键词: NSERC; CREATE; Biological; information; processing

The core of our program is the training of graduate students to be productive team members, not just research subordinates. Current postgraduate training programs at U of L and in Alberta generally are characterized by a very high standard of science but they have been focused on a limited range of research approaches. The proposed programme will enable the establishment of a world-class training environment for students and post-doctoral trainees in the field of information processing in biological systems, integrating cell biology, dynamic imaging, and neurocomputation. Our proposal is based upon the idea that the next generation of innovators in life science must have a tool kit that contains methods for seeing intracellular molecular processes, for measuring activity of large distributed networks of cells, and for computation as it applies to both signal processing and cellular systems theoretical modeling. Our program now has acknowledged world-class expertise and infrastructure for advanced behavioural/cognitive neuroscience study, neuroanatomy, adult neurogenesis, molecular biology, magnetic resonance imaging, epigenetics, and high-density human EEG. With our recent Polaris Award, there is an integrated group of 5 new faculty who have particular expertise in neurocomputation, ensemble neurophysiological recording of large populations of individual neurons, and whole brain imaging of immediate early gene activation. Our co-applicants through collaborations add strengths in epigenetic programming, transgenic models, and stem cell regulation. When fully established, we expect to be training at any given time: 10-12 PDFs; 22-24 graduate students and 8 undergraduate trainees. Nearly all of the funding will be targeted at graduate education. Other funding will come through Alberta Innovates, existing grant sources and the Polaris program. This training will contribute significantly to a new generation of Canadian neuro/life scientists who are equally at home with a microscope or microelectrode, as with a supercomputer. This combination is essential for innovation in this part of life science and in its application in the future.

我们计划的核心是培养研究生成为富有成效的团队成员，而不仅仅是研究下属。目前在L的U和阿尔伯塔的研究生培训计划一般是由一个非常高的科学标准的特点，但他们一直专注于研究方法的范围有限。拟议的方案将能够建立一个世界级的培训环境，为学生和博士后学员在生物系统的信息处理领域，整合细胞生物学，动态成像和神经计算。我们的建议是基于这样的想法，即下一代的创新者在生命科学必须有一个工具包，其中包含的方法，看到细胞内的分子过程，测量活动的大型分布式网络的细胞，并计算，因为它适用于信号处理和细胞系统的理论建模。我们的计划现在已经承认先进的行为/认知神经科学研究，神经解剖学，成人神经发生，分子生物学，磁共振成像，表观遗传学和高密度人类EEG的世界一流的专业知识和基础设施。随着我们最近的北极星奖，有5个新的教师谁在神经计算，单个神经元的大群体的合奏神经生理学记录，和立即早期基因激活的全脑成像的特殊专业知识的综合组。我们的共同申请人通过合作增加了表观遗传编程，转基因模型和干细胞调控方面的优势。当完全建立，我们预计将在任何给定的时间培训：10-12 PDF; 22-24研究生和8个本科学员。几乎所有的资金都将用于研究生教育。其他资金将来自阿尔伯塔创新，现有的赠款来源和北极星计划。这项培训将大大有助于新一代加拿大神经/生命科学家谁是同样在家里与显微镜或微电极，作为一个超级计算机。这种结合对于生命科学这一部分的创新及其未来的应用至关重要。