NSERC CREATE in Biological information processing: From genome to systems level

NSERC CREATE 生物信息处理：从基因组到系统水平

• 批准号: 414018-2012
• 负责人: Sutherland, Robert
• 金额: $ 21.86万
• 依托单位: University of Lethbridge
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Training Experience
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628778
• 关键词: NSERC; CREATE; Biological; information; processing

The core of our program is the training of graduate students to be productive team members, not just research subordinates. Current postgraduate training programs at U of L and in Alberta generally are characterized by a very high standard of science but they have been focused on a limited range of research approaches. The proposed programme will enable the establishment of a world-class training environment for students and post-doctoral trainees in the field of information processing in biological systems, integrating cell biology, dynamic imaging, and neurocomputation. Our proposal is based upon the idea that the next generation of innovators in life science must have a tool kit that contains methods for seeing intracellular molecular processes, for measuring activity of large distributed networks of cells, and for computation as it applies to both signal processing and cellular systems theoretical modeling. Our program now has acknowledged world-class expertise and infrastructure for advanced behavioural/cognitive neuroscience study, neuroanatomy, adult neurogenesis, molecular biology, magnetic resonance imaging, epigenetics, and high-density human EEG. With our recent Polaris Award, there is an integrated group of 5 new faculty who have particular expertise in neurocomputation, ensemble neurophysiological recording of large populations of individual neurons, and whole brain imaging of immediate early gene activation. Our co-applicants through collaborations add strengths in epigenetic programming, transgenic models, and stem cell regulation. When fully established, we expect to be training at any given time: 10-12 PDFs; 22-24 graduate students and 8 undergraduate trainees. Nearly all of the funding will be targeted at graduate education. Other funding will come through Alberta Innovates, existing grant sources and the Polaris program. This training will contribute significantly to a new generation of Canadian neuro/life scientists who are equally at home with a microscope or microelectrode, as with a supercomputer. This combination is essential for innovation in this part of life science and in its application in the future.

我们项目的核心是培养研究生成为富有成效的团队成员，而不仅仅是研究下属。目前，多伦多大学和阿尔伯塔省的研究生培训项目总体上以很高的科学标准为特点，但它们专注于有限的研究方法。该计划将为生物系统信息处理领域的学生和博士后学员建立一个世界级的培训环境，整合细胞生物学，动态成像和神经计算。我们的建议是基于这样一个想法，即下一代生命科学的创新者必须拥有一个工具包，其中包含了观察细胞内分子过程的方法，用于测量大型分布式细胞网络的活动，以及用于信号处理和细胞系统理论建模的计算方法。我们的项目目前在高级行为/认知神经科学研究、神经解剖学、成人神经发生、分子生物学、磁共振成像、表观遗传学和高密度人类脑电图方面拥有世界一流的专业知识和基础设施。我们最近获得了北极星奖，这是一个由5名新教师组成的综合小组，他们在神经计算、大量单个神经元的整体神经生理学记录和早期基因激活的全脑成像方面具有特殊的专业知识。我们的共同申请者通过合作增加了在表观遗传编程，转基因模型和干细胞调控方面的优势。当完全建立后，我们希望在任何给定的时间进行培训：10-12 pdf；研究生22-24人，本科生8人。几乎所有的资金都将用于研究生教育。其他资金将通过阿尔伯塔创新，现有的赠款来源和北极星计划。这项培训将对新一代加拿大神经/生命科学家做出重大贡献，这些科学家将像使用超级计算机一样熟练使用显微镜或微电极。这种结合对于生命科学这一领域的创新及其未来的应用至关重要。