NSERC CREATE in Biological information processing: From genome to systems level

NSERC CREATE 生物信息处理：从基因组到系统水平

• 批准号: 414018-2012
• 负责人: Sutherland, Robert
• 金额: $ 21.86万
• 依托单位: University of Lethbridge
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Training Experience
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628778
• 关键词: NSERC; CREATE; Biological; information; processing

The core of our program is the training of graduate students to be productive team members, not just research subordinates. Current postgraduate training programs at U of L and in Alberta generally are characterized by a very high standard of science but they have been focused on a limited range of research approaches. The proposed programme will enable the establishment of a world-class training environment for students and post-doctoral trainees in the field of information processing in biological systems, integrating cell biology, dynamic imaging, and neurocomputation. Our proposal is based upon the idea that the next generation of innovators in life science must have a tool kit that contains methods for seeing intracellular molecular processes, for measuring activity of large distributed networks of cells, and for computation as it applies to both signal processing and cellular systems theoretical modeling. Our program now has acknowledged world-class expertise and infrastructure for advanced behavioural/cognitive neuroscience study, neuroanatomy, adult neurogenesis, molecular biology, magnetic resonance imaging, epigenetics, and high-density human EEG. With our recent Polaris Award, there is an integrated group of 5 new faculty who have particular expertise in neurocomputation, ensemble neurophysiological recording of large populations of individual neurons, and whole brain imaging of immediate early gene activation. Our co-applicants through collaborations add strengths in epigenetic programming, transgenic models, and stem cell regulation. When fully established, we expect to be training at any given time: 10-12 PDFs; 22-24 graduate students and 8 undergraduate trainees. Nearly all of the funding will be targeted at graduate education. Other funding will come through Alberta Innovates, existing grant sources and the Polaris program. This training will contribute significantly to a new generation of Canadian neuro/life scientists who are equally at home with a microscope or microelectrode, as with a supercomputer. This combination is essential for innovation in this part of life science and in its application in the future.

我们项目的核心是将研究生培养成为富有成效的团队成员，而不仅仅是研究下属。伦敦大学和阿尔伯塔省目前的研究生培训项目总体上具有很高的科学标准，但它们的研究方法范围有限。拟议的项目将为生物系统信息处理领域的学生和博士后学员建立世界一流的培训环境，整合细胞生物学、动态成像和神经计算。我们的提议基于这样的想法：生命科学的下一代创新者必须拥有一个工具包，其中包含用于观察细胞内分子过程、测量大型分布式细胞网络的活动以及适用于信号处理和细胞系统理论建模的计算的方法。我们的项目现在拥有公认的世界一流的专业知识和基础设施，用于先进的行为/认知神经科学研究、神经解剖学、成人神经发生、分子生物学、磁共振成像、表观遗传学和高密度人类脑电图。我们最近获得的北极星奖是由 5 名新教师组成的综合团队，他们在神经计算、大量个体神经元的整体神经生理学记录以及即时早期基因激活的全脑成像方面拥有特殊的专业知识。我们的共同申请人通过合作增加了表观遗传编程、转基因模型和干细胞调控方面的优势。完全建立后，我们希望在任何给定时间进行培训：10-12 个 PDF；研究生22-24人，本科生8人。几乎所有资金都将用于研究生教育。其他资金将来自阿尔伯塔创新局、现有拨款来源和北极星计划。这项培训将为新一代加拿大神经/生命科学家做出重大贡献，他们像使用超级计算机一样熟悉显微镜或微电极。这种结合对于生命科学这一部分及其未来应用的创新至关重要。