Hippocampus and memory: A systems level approach

海马体和记忆：系统级方法

• 批准号: RGPIN-2018-04724
• 负责人: Sutherland, Robert
• 金额: $ 4.74万
• 依托单位: University of Lethbridge
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=691333
• 关键词: Hippocampus; memory; systems; level; approach

The hippocampus is situated at the hub of a set of distributed cortical networks that represent movement and perceptual information. Amnesia is the most prominent effect of damage to or dysfunction of the hippocampus and most forms of human memory disorder involve the hippocampus. The current proposal examines in detail how the interactions between the hippocampus and other cortical networks establishes long-term memories. We use a combination of molecular markers of cellular activation imaged across the whole cortex, temporary***inactivation of hippocampus and connected regions using microinjections of inhibitors or designed receptors exclusively activated by designer drugs (DREADDs), and hippocampus-relevant memory tasks. We will discover exactly which types of information depend on the hippocampus and how the hippocampus modifies the functioning of the cortex through long-term interactions.

海马体位于一组分布式皮质网络的中心，这些网络代表运动和感知信息。记忆障碍是海马体损伤或功能障碍的最突出的影响，大多数形式的人类记忆障碍都涉及海马体。目前的提议详细研究了海马体和其他皮质网络之间的相互作用如何建立长期记忆。我们使用了一种组合的分子标记的细胞激活成像整个皮层，暂时 * 失活海马和连接区域使用显微注射的抑制剂或设计的受体专门激活的设计药物（DREADDs），和海马相关的记忆任务。我们将确切地发现哪些类型的信息依赖于海马体，以及海马体如何通过长期相互作用来修改皮层的功能。