Genetic Basis of Coleopteran Vectorial Capacity for Bean pod mottle virus Transmission

鞘翅目豆荚斑驳病毒传播媒介能力的遗传基础

• 批准号: RGPIN-2016-04335
• 负责人: Cassone, Bryan
• 金额: $ 2.26万
• 依托单位: Brandon University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629098
• 关键词: Genetic; Basis; Coleopteran; Vectorial; Capacity

Why do some leaf–feeding arthropods transmit plant pathogens while others do not? Moreover, why typically are only a small minority of individuals within a vector species proficient at transmitting a particular pathogen? A considerable number of coleopteran beetles transmit viruses that cause disease to economically important vegetables and crops. However, the degree of variation within and among beetle species in their ability to harbor and transmit pathogens is remarkable (i.e. their vector competence). The genetic makeup of the vector undoubtedly contributes significantly to its susceptibility to pathogen infection and transmission, yet characterization of specific genes that influence vector competence has proven elusive. The long–term goal of the proposed research is to understand the genetic interactions and mechanisms of pathogen transmission by insects. Identifying genes that disrupt vector-mediated pathogen transmission will lead to novel and promising avenues for disease control. The proposed research will harness the unique attributes of a soybean pathosystem, consisting of three beetle species that exhibit individual and species level variation in their ability to vector a soybean virus that is prevalent in North America,

为什么一些食叶节肢动物传播植物病原体，而另一些不？此外，为什么在一个病媒物种中，通常只有一小部分人精通传播某种病原体？相当数量的鞘翅目甲虫传播病毒，导致经济上重要的蔬菜和作物的疾病。然而，甲虫种内和种间在窝藏和传播病原体的能力（即它们的传病媒介能力）方面的变化程度是显著的。载体的遗传组成无疑对其对病原体感染和传播的易感性有重要贡献，但影响载体能力的特定基因的表征已被证明是难以捉摸的。拟议研究的长期目标是了解昆虫传播病原体的遗传相互作用和机制。鉴定破坏载体介导的病原体传播的基因将导致疾病控制的新的和有前途的途径。拟议的研究将利用大豆病理系统的独特属性，由三种甲虫组成，它们在传播北美流行的大豆病毒的能力方面表现出个体和物种水平的差异，