Prediction of natural killer cell education and repertoire formation by donor immunogenetics

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Natural killer (NK) cells are white blood cells that are part of the immune system, and have not been studied extensively. We do not yet understand how NK cells function because the genes and molecules that control them are very complex, and we are still establishing the tools and computational programs to study this complexity. Our NSERC program aims to understand how genes and molecules control NK cells to make them function differently between people. We are hoping to understand the extent of NK cell diversity, and how a limited number of genes can lead to such dramatic changes in the function of the immune system.