Satellite cell activation and its paracrine impact on fiber phenotype

卫星细胞激活及其旁分泌对纤维表型的影响

• 批准号: RGPIN-2015-03833
• 负责人: Anderson, Judy
• 金额: $ 3.28万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629221
• 关键词: Satellite; cell; activation; its; paracrine

I explore the fundamental regulation of satellite cells (SC) in muscle; I aim to improve animal-meat production by understanding muscle growth. The known biology of SC, stem cells in muscle, and 2-way SC interactions with muscle fibers and tissues is mostly based on mouse muscle. SC activation to cycle is the first step in growth and regeneration; my explicit focus on that step is nearly unique. Since 2009, I initiated a comparative approach to study SC regulation and activation: we focused on the regulation of zebrafish muscle SC and differences from that of mouse SC, since new findings could be potent if applied to boost aquaculture fish-meat production. The proposed work aims to understand the interplay of SC activity with muscle development, function and regeneration and will advance Canadian innovation capacity in promoting high-quality meat growth in animals.

我探索了肌肉中卫星细胞（SC）的基本调节；我的目标是通过了解肌肉生长来提高动物肉类产量。已知的SC生物学，肌肉中的干细胞，以及SC与肌肉纤维和组织的双向相互作用主要基于小鼠肌肉。SC激活循环是生长和再生的第一步；我对这一步的明确关注几乎是独一无二的。自2009年以来，我发起了一种比较方法来研究SC的调节和激活：我们专注于斑马鱼肌肉SC的调节以及与小鼠SC的差异，因为新的发现可能是有效的，如果应用于提高水产养殖鱼肉产量。拟议的工作旨在了解SC活动与肌肉发育、功能和再生的相互作用，并将提高加拿大在促进动物高质量肉类生长方面的创新能力。