Inter-kingdom Signalling: Modulation of Mast cells by Commensal Bacteria

界间信号传导：共生细菌对肥大细胞的调节

• 批准号: RGPIN-2016-06109
• 负责人: Forsythe, Paul
• 金额: $ 2.4万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629251
• 关键词: Inter; kingdom; Signalling; Modulation; Mast

Mast cells long regarded as key effectors of human allergic disease are now considered primary inducers and amplifiers of both innate and adaptive immune responses. Their presence in high numbers in the airway and gut mucosa is indicative of their role as important gatekeepers/sentinels for fighting infectious organisms at these portals of entry. However, the position of mast cells on the frontline of defense against pathogens also suggests they may play an important role in fostering the host-microbiome relationship and maintaining the complex ecosystem of the super-organism.

肥大细胞长期以来被认为是人类过敏性疾病的关键效应器，现在被认为是先天性和适应性免疫应答的主要诱导剂和放大剂。它们在气道和肠粘膜中的大量存在表明它们作为重要的守门人/哨兵在这些入口处对抗感染性生物体的作用。然而，肥大细胞在防御病原体的前线的地位也表明它们可能在促进宿主-微生物组关系和维持超级有机体的复杂生态系统方面发挥重要作用。