Inter-kingdom Signalling: Modulation of Mast cells by Commensal Bacteria

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Mast cells long regarded as key effectors of human allergic disease are now considered primary inducers and amplifiers of both innate and adaptive immune responses. Their presence in high numbers in the airway and gut mucosa is indicative of their role as important gatekeepers/sentinels for fighting infectious organisms at these portals of entry. However, the position of mast cells on the frontline of defense against pathogens also suggests they may play an important role in fostering the host-microbiome relationship and maintaining the complex ecosystem of the super-organism.