A New Cellular Protein Degradation Pathway for Lysosome Homeostasis and Remodeling

溶酶体稳态和重塑的新细胞蛋白降解途径

• 批准号: RGPIN-2017-06652
• 负责人: Brett, Christopher
• 金额: $ 2.04万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629285
• 关键词: New; Cellular; Protein; Degradation; Pathway

Although they may not be aware, everyone recycles to sustain life on earth – at least from the perspective of a cell biologist. This is because all eukaryotic cells, including those that constitute you and I, rely on organelles called lysosomes to recycle biomaterials. Lysosomes recycle unneeded or damaged cellular components, and clear extracellular debris or pathogens by converting them into an important source of nutrients. As such, lysosome activity is needed to sustain metabolism when cells are starved, and to remove toxic biomaterials that accumulate in cells as they age. To function, these dynamic organelles rely on nutrient transporters to return products of catabolism (amino acids, lipids, nucleic acids) to the cell for reuse. But little is know about these transporters including how they are regulated or degraded. Until recently, when we discovered a new process in the model organism

虽然他们可能没有意识到，但每个人都在努力维持地球上的生命-至少从细胞生物学家的角度来看。这是因为所有的真核细胞，包括那些组成你和我的细胞，都依赖于称为溶酶体的细胞器来回收生物材料。溶酶体回收不需要的或受损的细胞成分，并通过将其转化为重要的营养来源来清除细胞外碎片或病原体。因此，当细胞饥饿时，需要溶酶体活性来维持代谢，并去除随着细胞老化而积累在细胞中的有毒生物材料。为了发挥作用，这些动态细胞器依赖于营养转运蛋白将催化剂（氨基酸，脂质，核酸）的产物返回细胞进行再利用。但对这些转运蛋白知之甚少，包括它们是如何被调节或降解的。直到最近，当我们在模式生物中发现了一个新的过程