Transcriptional and epigenetic determinants of the epithelial-mesenchymal transition

上皮-间质转化的转录和表观遗传决定因素

• 批准号: RGPIN-2017-05018
• 负责人: Vanderhyden, Barbara
• 金额: $ 1.89万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629363
• 关键词: Transcriptional; epigenetic; determinants; epithelial; mesenchymal

Each cell type in every tissue of the body has a unique identity associated with its particular function. Whether it is a stem cell, neuron, muscle or skin cell, its unique identity is established by the expression of a unique set of genes. For some cells, however, their identity has considerable flexibility (plasticity) that allows them to change their shape and behavior as they respond to environmental cues. These transitions are normally context-specific, but there is growing evidence for certain commonalities among different cell types undergoing similar changes. A notable example is the epithelial-to-mesenchymal transition, or EMT.

身体每种组织中的每种细胞类型都具有与其特定功能相关的独特身份。无论是干细胞、神经元、肌肉还是皮肤细胞，其独特的身份都是由一组独特的基因表达建立的。然而，对于某些细胞来说，它们的身份具有相当大的灵活性（可塑性），使它们能够在响应环境线索时改变它们的形状和行为。这些转变通常是特定于环境的，但越来越多的证据表明，在经历类似变化的不同细胞类型之间存在某些共性。一个值得注意的例子是上皮向间充质转化，或EMT。