Structural and Functional Studies of Spliceosome Assembly and Activation
Structural and Functional Studies of Spliceosome Assembly and Activation
批准号:
RGPIN-2016-05175
负责人:
MacMillan, Andrew
金额:
$2.77万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-12-31
中文摘要
真核生物中的前信使RNA(pre-mRNAs)是一种分裂基因结构,编码外显子序列由非编码内含子序列分隔。内含子被切除和外显子连接在一起的过程被称为前mRNA剪接,由RNA-蛋白质复合体-剪接体催化,剪接体从酵母到人类都高度保守。虽然组成性剪接事件的忠实执行是功能mRNAs成熟所必需的,但选择性剪接事件在高等真核细胞的分化和发育以及病毒的生命周期中代表了基因调控的基本水平。
英文摘要
Pre-messenger RNAs (pre-mRNAs) in eukaryotes are characterized by a split-gene structure where coding exon sequences are separated by non-coding intron sequences. The process by which introns are excised and exons are joined together is known as pre-mRNA splicing and is catalyzed by an RNA-protein complex, the spliceosome, that is highly conserved from yeast to humans. While the faithful execution of constitutive splicing events is required for the maturation of functional mRNAs, alternative splicing events represent a fundamental level of gene regulation in terms of differentiation and development in higher eukaryotic cells and in the life cycle of viruses.
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会议论文
Modelling of novel pyrometallurgical by-product handling system
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批准号:533159-2018
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项目类别:Experience Awards (previously Industrial Undergraduate Student Research Awards)
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资助金额:$0.33万
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财政年份:2018
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负责人:MacMillan, Andrew
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依托单位:
Structural and Functional Studies of Spliceosome Assembly and Activation
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批准号:RGPIN-2016-05175
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.77万
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财政年份:2018
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负责人:MacMillan, Andrew
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依托单位:
Structural and Functional Studies of Spliceosome Assembly and Activation
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批准号:RGPIN-2016-05175
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.77万
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财政年份:2016
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负责人:MacMillan, Andrew
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依托单位:
Mechanistic investigations of the role of RNA in gene regulation
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批准号:194341-2011
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2015
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负责人:MacMillan, Andrew
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依托单位:
Mechanistic investigations of the role of RNA in gene regulation
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批准号:194341-2011
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2014
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负责人:MacMillan, Andrew
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依托单位:
Mechanistic investigations of the role of RNA in gene regulation
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批准号:194341-2011
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2013
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负责人:MacMillan, Andrew
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依托单位:
Mechanistic investigations of the role of RNA in gene regulation
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批准号:194341-2011
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2012
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负责人:MacMillan, Andrew
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依托单位:
Mechanistic investigations of the role of RNA in gene regulation
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批准号:194341-2011
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2011
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负责人:MacMillan, Andrew
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依托单位:
Mechanisms of RNA interference in eukaryotic cells
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批准号:194341-2006
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.83万
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财政年份:2010
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负责人:MacMillan, Andrew
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依托单位:
Mechanisms of RNA interference in eukaryotic cells
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批准号:194341-2006
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.83万
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财政年份:2009
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负责人:MacMillan, Andrew
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依托单位:
Mechanisms of RNA interference in eukaryotic cells
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批准号:194341-2006
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.83万
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财政年份:2008
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负责人:MacMillan, Andrew
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依托单位:
Mechanisms of RNA interference in eukaryotic cells
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批准号:194341-2006
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.83万
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财政年份:2006
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负责人:MacMillan, Andrew
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依托单位:
Chemical probes of RNA dynamics
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批准号:194341-2001
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.75万
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财政年份:2005
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负责人:MacMillan, Andrew
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依托单位:
Chemical probes of RNA dynamics
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批准号:194341-2001
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.75万
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财政年份:2004
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负责人:MacMillan, Andrew
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依托单位:
Chemical probes of RNA dynamics
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批准号:194341-2001
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.75万
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财政年份:2003
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负责人:MacMillan, Andrew
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依托单位:
Chemical probes of RNA dynamics
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批准号:194341-2001
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项目类别:Discovery Grants Program - Individual
-
资助金额:$3.75万
-
财政年份:2002
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负责人:MacMillan, Andrew
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依托单位:
Chemical probes of RNA dynamics
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批准号:194341-2001
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.75万
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财政年份:2001
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负责人:MacMillan, Andrew
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依托单位:
Chemical probes of RNA splicing reactions
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批准号:194341-1999
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项目类别:Discovery Grants Program - Individual
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资助金额:$0.68万
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财政年份:2000
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负责人:MacMillan, Andrew
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依托单位:
Chemical probes of RNA splicing reactions
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批准号:194341-1999
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.7万
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财政年份:2000
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负责人:MacMillan, Andrew
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依托单位:
Chemical probes of RNA splicing reactions
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批准号:194341-1999
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.38万
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财政年份:1999
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负责人:MacMillan, Andrew
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依托单位:
国内基金
海外基金
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批准号:--
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项目类别:--
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资助金额:160万元
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批准年份:2022
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依托单位:
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批准号:11001084
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项目类别:青年科学基金项目
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资助金额:16.0万元
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批准年份:2010
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依托单位:
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批准号:30771013
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项目类别:面上项目
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