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Epigenetic regulation of repeat expression by RB and EZH2 in cancer

Epigenetic regulation of repeat expression by RB and EZH2 in cancer
癌症中 RB 和 EZH2 重复表达的表观遗传调控
批准号：
370044
负责人：
Dick Frederick A
金额：
$63.53万
依托单位：
London Health Sciences Centre Res. Inc. (Ont.)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-09-01 至 2022-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=370044&lang=en
关键词：
Cancer Endogenous Retrovirus Heterochromatin Histone Methyl Transferase Line Element Mutation Retinoblastoma Retrotransposition Transgenic Mouse

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英文摘要
Cancer cells possess a number of features that distinguish them from the normal cells in our bodies. This grant application is focused on studying the remnants of ancient infections that leave behind foreign DNA sequences called repeats. Their expression
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Chromosome organization by RB and Condensin II in metastasis.
Roles of retrotransposon silencing in genome instability and cancer therapy
Integration of proliferative control mechanisms by the RB protein
Differential control of E2F transcription factors by pRB in normal and cancer cells
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