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Differential control of E2F transcription factors by pRB in normal and cancer cells

Differential control of E2F transcription factors by pRB in normal and cancer cells
正常细胞和癌细胞中 pRB 对 E2F 转录因子的差异控制
批准号：
223272
负责人：
Dick Frederick A
金额：
$31.63万
依托单位：
London Health Sciences Centre Res. Inc. (Ont.)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2011
资助国家：
加拿大
项目状态：
已结题
起止时间：
2011-03-01 至 2014-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=223272&lang=en
关键词：
Apoptosis Cell Cycle Dna Damage Gene-Targeted Mice Signal Transduction Transcription

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英文摘要
Human cancer arises when normal cells sustain damage to their DNA, acquire permanent change to their genes, and as a result proliferate uncontrollably. The study of cells derived from human tumors has revealed that mutations disrupting cell proliferation
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