Strategies for enhancement of bioactive flavonol glycosides in plants

增强植物中生物活性黄酮醇苷的策略

• 批准号: RGPIN-2015-03950
• 负责人: Bozzo, Gale
• 金额: $ 1.75万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630323
• 关键词: Strategies; enhancement; bioactive; flavonol; glycosides

Flavonols (e.g. quercetin) are well known phytochemicals. Their incorporation in the human diet may prevent accumulation of damaging radicals associated with chronic diseases including Alzheimer’s. Approximately 5% of Canadians over the age of 65 are diagnosed with some form of dementia. Flavonols offer a preventative measure to offset the $33 billion spent annually to treat these disorders in Canada. In the human diet, flavonols are not as available as their glycosides, forms which tend to predominate across vegetative (e.g. onion, kale, broccoli) and fruit (e.g. apple, grape, pepper, tomato) tissues. In plants, flavonols exists as conjugates of one or more sugars, including monoglycosides, diglycosides and bisglycosides (e.g. quercetin 3-

黄酮醇（例如槲皮素）是众所周知的植物化学物质。将它们纳入人类饮食中可以防止与包括阿尔茨海默氏症在内的慢性疾病相关的破坏性自由基的积累。大约5%的65岁以上的加拿大人被诊断患有某种形式的痴呆症。黄酮醇提供了一种预防措施，以抵消加拿大每年用于治疗这些疾病的330亿美元。在人类饮食中，黄酮醇不像它们的糖苷那样可用，糖苷形式倾向于在植物（例如洋葱，羽衣甘蓝，花椰菜）和水果（例如苹果，葡萄，辣椒，番茄）组织中占主导地位。在植物中，黄酮醇作为一种或多种糖的缀合物存在，包括单糖苷、二糖苷和双糖苷（例如槲皮素3-糖苷）。