Analysis of the molecular mechanisms of plant defense against microbial pathogens
Analysis of the molecular mechanisms of plant defense against microbial pathogens
批准号:
RGPIN-2017-04690
负责人:
Zhang, Yuelin
金额:
$4.23万
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-12-31
中文摘要
感知和防御微生物感染对多细胞生物的生存至关重要。植物主要使用两种类型的免疫受体来识别病原体并激活下游防御反应。跨膜受体用于识别细菌鞭毛蛋白等微生物的保守特征,而具有核苷酸结合和富含亮氨酸重复结构域(NLRs)的细胞内受体用于检测分泌到植物细胞中促进定植的病原体的特定蛋白质。本研究旨在了解这两种免疫受体介导的免疫是如何在分子水平上调控的。
英文摘要
Sensing and defending against microbial infection is essential to the survival of multicellular organisms. Plants mainly use two types of immune receptors to recognize pathogens and activate downstream defense responses. Transmembrane receptors are used to recognize conserved features of microbes such as bacterial flagellin, whereas intracellular receptors with nucleotide binding and leucine-rich repeats domains (NLRs) are used to detect specific proteins from pathogens that are secreted into the plant cell to promote colonization. The proposed research aims to understand how immunity mediated by these two types of immune receptors is regulated at molecular level.
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