Role of PEDF/ATGL signalling in the central control of energy homeostasis

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In the central nervous system, the hypothalamus plays a key role in regulating energy intake and expenditure by integrating circulating metabolic and hormonal signals. These signals directly modulate the activity of hypothalamic neurons to coordinate appropriate behavioural and physiological responses to maintain energy homeostasis. Fatty acids (FA) act in hypothalamic cells to regulate feeding and glucose homeostasis. However, the mechanisms involved remain elusive. Besides circulating FA, the role of neutral glycerolipid lipases that generate FA from intracellular triglycerides (TG) stores in the regulation of energy balance has not been explored.