Smooth muscle molecular mechanics

平滑肌分子力学

• 批准号: RGPIN-2015-05054
• 负责人: Lauzon, AnneMarie
• 金额: $ 2.91万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630603
• 关键词: Smooth; muscle; molecular; mechanics

Smooth muscle is found in all hollow organs of the body (e.g. intestine, bladder, blood vessels). Smooth muscle is unique in its ability to generate and maintain force for long periods of time, at low energy cost. Once stimulated to contract, smooth muscle can modulate its rate of energy consumption within the time course of a single contraction. This property, called the latch-state, is an important characteristic of smooth muscle but remains poorly understood. Thus, the overarching goal of this program of research is to understand the molecular mechanism behind the latch-state.

平滑肌存在于身体的所有中空器官（例如肠、膀胱、血管）中。平滑肌在其以低能量成本长时间产生和维持力的能力方面是独特的。一旦刺激收缩，平滑肌可以在单次收缩的时间过程中调节其能量消耗速率。这种特性，称为闭锁状态，是平滑肌的一个重要特征，但仍然知之甚少。因此，这项研究计划的首要目标是了解闩锁状态背后的分子机制。