Integrative physiology of animal performance during environmental stress

环境应激期间动物表现的综合生理学

• 批准号: 418202-2012
• 负责人: Scott, Graham
• 金额: $ 2.33万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630989
• 关键词: Integrative; physiology; animal; performance; during

Environmental hypoxia (low oxygen), whether it is naturally occurring or induced by human activities, can impact the survival and performance of animals in the wild. All vertebrates have some capacity for responding to hypoxia, but there are clearly some species that are more capable of thriving in hypoxic environments than others. Although we know a great deal about the mechanisms of hypoxia tolerance in some exceptionally tolerant vertebrates, it is unclear if the knowledge gained from studying these animals can be generalized to different species with different tolerances. My research program addresses this gap in our knowledge by studying the natural variation in hypoxia tolerance within and across vertebrate groups. I will use integrative physiological methodologies to explain - from molecular to organismal levels - how fish, mammals, and birds are able to live and perform in hypoxic environments. A comparative evolutionary approach will be used to identify, ascribe adaptive significance to, and provide environmental relevance for the respiratory and metabolic mechanisms of hypoxia tolerance. This will be combined with a model species approach that can provide developmental and genomic insights that are impractical to explore in non-model organisms. Global change is making hypoxia a new reality for many animals, from aquatic species living in eutrophic environments to terrestrial species seeking cooler temperatures at high altitude. The proposed research is important because it will explain how different species, with different hypoxia tolerances, are likely to be affected by global change, and will thus identify the species that are most at risk. The grant will allow me to complete the training of 1 Ph.D., 3 M.Sc., and 10 B.Sc. students with advanced skills and techniques that are invaluable for many scientific careers, and to begin training two additional graduate students. My work will make significant impacts by helping understand and protect our natural environment for the health, quality of life, and economic benefit of Canadians.

环境缺氧（低氧），无论是自然发生的还是由人类活动引起的，都会影响野生动物的生存和表现。所有脊椎动物都有对缺氧做出反应的能力，但显然有些物种在缺氧环境中比其他物种更能茁壮成长。虽然我们知道很多关于缺氧耐受性的机制在一些特别耐受脊椎动物，目前还不清楚，如果从研究这些动物获得的知识可以推广到不同的物种具有不同的耐受性。我的研究项目通过研究脊椎动物群体内和跨脊椎动物群体的缺氧耐受性的自然变化来解决我们知识中的这一差距。我将使用综合生理学方法来解释-从分子到有机体水平-鱼类，哺乳动物和鸟类如何能够在缺氧环境中生活和表演。比较进化的方法将被用来识别，归因于适应性的意义，并提供缺氧耐受性的呼吸和代谢机制的环境相关性。这将与模式物种方法相结合，该方法可以提供在非模式生物中探索不切实际的发育和基因组见解。全球变化正在使缺氧成为许多动物的新现实，从生活在富营养环境中的水生物种到在高海拔寻求较低温度的陆生物种。这项拟议中的研究很重要，因为它将解释具有不同缺氧耐受性的不同物种如何可能受到全球变化的影响，从而确定风险最大的物种。这笔赠款将使我能够完成1个博士学位的培训，3名硕士，和10名拥有先进技能和技术的B.Sc.学生，这些技能和技术对许多科学事业都是无价的，并开始再培训两名研究生。我的工作将通过帮助了解和保护我们的自然环境，为加拿大人的健康，生活质量和经济利益产生重大影响。