Comparative and Environmental Physiology

比较和环境生理学

• 批准号: 1000230557-2014
• 负责人: Scott, Graham
• 金额: $ 4.37万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=690913
• 关键词: Comparative; Environmental; Physiology

Nearly all animals require a steady supply of oxygen. Oxygen limitation which can arise clinically or in many extreme environments in nature can be catastrophic to normal cellular function. And yet, some unique species of mammals, birds, and fish thrive in environments where oxygen is scarce. The proposed research will elucidate how the physiology of these species is unique compared to most others, and how cellular and mitochondrial function is maintained during oxygen deprivation. It will thus elucidate natures solutions to an important clinical and environmental problem.

几乎所有的动物都需要稳定的氧气供应。在临床上或自然界中的许多极端环境中可能出现的氧限制可能对正常细胞功能造成灾难性影响。然而，一些独特的哺乳动物，鸟类和鱼类在氧气稀缺的环境中茁壮成长。拟议的研究将阐明这些物种的生理学与大多数其他物种相比是如何独特的，以及细胞和线粒体功能在缺氧期间是如何维持的。因此，它将阐明一个重要的临床和环境问题的自然解决方案。