Role of dopamine in the maturation of prefrontal cortex and associated behaviors.

多巴胺在前额皮质成熟和相关行为中的作用。

• 批准号: RGPIN-2015-04761
• 负责人: Srivastava, Lalit
• 金额: $ 2.4万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=631437
• 关键词: Role; dopamine; maturation; prefrontal; cortex

The refinement of mature cognitive, motivational and social behaviors typically takes place during adolescence, and is linked to the protracted development of the prefrontal cortex (PFC). Among neural inputs to the PFC, the mesofrontal dopamine (DA) system is interesting as DAergic afferents peak when key organizational events are taking place in the PFC. DAergic signaling, besides its acute effects on cortical excitatory and inhibitory neuron excitability, also mediates synaptic remodeling and long-term plasticity. While a large body of literature exists on the role of adult DA system, very little is known of the long-term consequences of early dysregulated DA homeostasis on the development of prefrontal networks and associated behaviors.

成熟的认知、动机和社会行为的完善通常发生在青春期，并与前额皮质（PFC）的长期发育有关。在PFC的神经输入中，中额叶多巴胺（DA）系统很有趣，因为当PFC发生关键组织事件时，DAergic传入信号达到峰值。DAergic信号除了对皮质兴奋性和抑制性神经元兴奋性产生急性影响外，还介导突触重塑和长期可塑性。虽然关于成人DA系统的作用已有大量文献，但对于早期DA稳态失调对前额叶网络发育和相关行为的长期影响知之甚少。