White matter neuroplasticity and motor learning

白质神经可塑性和运动学习

• 批准号: RGPIN-2017-04154
• 负责人: Boyd, Lara
• 金额: $ 2.84万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=631468
• 关键词: White; matter; neuroplasticity; motor; learning

The human brain is remarkably neuroplastic, yet most studies have focused nearly exclusively on neuroplasticity in the cortical gray matter. Until recently we thought that white matter structures in the brain had little potential for experience-dependent neuroplastic change. Recent work from rodent models suggests that this is incorrect; however, this question has not been considered in humans. The main hypothesis being tested in the proposed work is that white matter, specifically myelin, is neuroplastic and supports experience dependent change associated with motor learning in the human brain.

人类大脑具有显著的神经可塑性，但大多数研究几乎只关注皮质灰质的神经可塑性。直到最近，我们还认为大脑中的白色物质结构几乎没有经历依赖性神经可塑性变化的潜力。最近啮齿动物模型的研究表明，这是不正确的;然而，这个问题还没有在人类中考虑过。在拟议的工作中测试的主要假设是，白色物质，特别是髓磷脂，是神经可塑性和支持经验依赖的变化与运动学习在人脑中。