The neural correlates of motor memory consolidation in the human brain

人脑运动记忆巩固的神经相关性

• 批准号: 401890-2011
• 负责人: Boyd, Lara
• 金额: $ 2.91万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=550711
• 关键词: neural; correlates; motor; memory; consolidation

Theoretical models of motor learning propose that skilled practice induces the formation of an internal model for movement. A key element in the development of internal models is the transference of memories from a fragile to a more permanent, robust and stable state. Evidence for this process stems from research that shows that following practice of skilled movements, changes continue to take place in the brain that both strengthen and modify memory for motor learning. The main aim of the present proposal is to elucidate the network of brain regions that are critical for the process of motor memory consolidation. The proposed program of research uniquely advances past work in this field in three main ways. First, it emphasizes the functional significance of regional brain activity during motor memory consolidation. Evolution of the network activated in association with motor learning is widely believed to support motor consolidation. Yet just because the activation of a brain area is changed by consolidation does not mean that area was responsible for supporting consolidation. It is possible that changes within one brain area were driven by another brain area. To reveal the brain regions supporting consolidation it is first necessary to identify those areas that are directly activated during consolidation. Using brain stimulation (transcranial magnetic stimulation) to disrupt the function of activated areas is one approach that allows the determination of which areas are essential for consolidation. Second, it will investigate whether the time course of motor memory consolidation is unique in different brain regions. Third, it will examine whether motor memory consolidation requires interhemispheric interactions. This work is important as greater understanding of the neural basis of memory consolidation will inform the evolution of conceptual models of how internal models are developed to support learned movements.

运动学习的理论模型认为，熟练的练习诱导形成运动的内部模型。开发内部模型的一个关键因素是将记忆从脆弱状态转变为更持久、更健壮和更稳定的状态。这一过程的证据来源于一项研究，该研究表明，在练习熟练的动作后，大脑中不断发生的变化，既加强和修改了运动学习的记忆。本提案的主要目的是阐明对运动记忆巩固过程至关重要的大脑区域网络。拟议的研究方案在三个主要方面独树一帜地推进了这一领域过去的工作。首先，强调了局部脑活动在运动记忆巩固过程中的功能意义。与运动学习相关的激活网络的进化被广泛认为支持运动巩固。然而，仅仅因为大脑区域的激活因合并而改变，并不意味着该区域负责支持合并。有可能一个脑区的变化是由另一个脑区驱动的。为了揭示支持巩固的大脑区域，首先需要确定那些在巩固过程中被直接激活的区域。使用脑刺激(经颅磁刺激)来扰乱激活区域的功能是一种方法，可以确定哪些区域是巩固所必需的。其次，它将调查运动记忆巩固的时间过程是否在不同的大脑区域是独特的。第三，它将研究运动记忆的巩固是否需要大脑半球之间的相互作用。这项工作很重要，因为更好地理解记忆巩固的神经基础将有助于概念模型的演变，即内部模型是如何发展的，以支持学习的运动。