Ecology of stress in wild fish in a changing world
不断变化的世界中野生鱼类的应激生态学
基本信息
- 批准号:RGPIN-2014-03897
- 负责人:
- 金额:$ 5.4万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2017
- 资助国家:加拿大
- 起止时间:2017-01-01 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The long-term goal of the Fish Ecology and Conservation Physiology Laboratory is to establish a clear understanding of the inter-relationships between the environment and individual-level physiology, behaviour, and fitness. In other words, we are interested in the ecology of stress. Stress is a part of the functional underpinning of ecology and plays a fundamental role in defining animal distribution and abundance. The neuro-endocrine stress axis (particularly the stimulation, synthesis, and release of glucocorticoids; GCs) integrates environmental information that influences life-history decisions such as those related to energy use and allocation, which ultimately influence fitness and survival. We focus on teleost fish, but unlike most previous research, do so in an ecological context using wild fish in field settings. Over the past five years our lab has made substantial progress in understanding stress in wild fish. However, the world is changing rapidly as a result of human activity, which means that fish are increasingly exposed to multiple stressors, some of which are novel. As such, our five-year goal for this NSERC Discovery Grant is to study the ecology of stress in wild fishes in the context of a changing world, attempting to understand (Theme A) how abiotic and biotic factors mediate stress responsiveness and (Theme B) the consequences of stress and stress responsiveness on organismal condition, behaviour, and fitness. The scientific approaches that will be used for hypothesis testing will include extensive experimentation and comparative surveys in natural field (e.g., lakes, rivers) and mesocosm (e.g., experimental ponds and streams) environments. For Theme A we will rely heavily on non-lethal blood sampling combined with electronic tagging. We will evaluate population-specific variation in stress responsiveness by assessing changes in cortisol, the principal GC in teleost fish, and also consider how habitat quality influences GC responsiveness. In some experiments we will expose fish to varied holding environments (e.g., manipulating thermal environment and flow) and evaluate GC responsiveness. For Theme B we will primarily use exogenous cortisol manipulations before releasing fish and observing the consequences of GC elevation. In some experiments we will evaluate how stressors influence wound healing in wild fish, while in other studies we will focus on reproductive success and survival endpoints. We will also manipulate environmental stressors and consider the potential for carryover effects across seasonal and life-history transitions. The proposed research is novel and has the potential to have a substantial influence on understanding ecological processes, particularly in the face of environmental change. The integrative research themes span the fundamental–applied continuum will provide a functional understanding of the effect of anthropogenic environmental change on organisms while elucidating the mechanistic relationships between physiological processes and population declines. For example, the work will reveal whether there is a mismatch between novel stressors and the GC response. The proposed work has substantial scope for training of highly qualified people and will help to ensure that the next generation of scientists has an understanding and appreciation for how human activities influence animal populations and the ecosystem services that these populations provide. In addition, there is considerable opportunity to engage the public and concerned stakeholders and generate knowledge of use to environmental managers.
鱼类生态及保育生理实验室的长远目标,是建立对环境与个体生理、行为和健康之间相互关系的清晰认识。换句话说,我们对压力的生态学很感兴趣。压力是生态学功能基础的一部分,在确定动物分布和丰度方面起着重要作用。神经-内分泌应激轴(尤其是糖皮质激素的刺激、合成和释放;GCs)整合了影响生命史决策的环境信息,如与能量使用和分配相关的决策,最终影响健康和生存。我们专注于硬骨鱼,但与大多数以前的研究不同,我们是在野外环境中使用野生鱼类的生态背景下进行研究的。在过去的五年中,我们的实验室在了解野生鱼类的压力方面取得了实质性进展。然而,由于人类活动,世界正在迅速变化,这意味着鱼类越来越多地暴露于多种压力源,其中一些是新的。因此,我们的五年目标是在不断变化的世界背景下研究野生鱼类的应激生态学,试图理解(主题a)非生物和生物因素如何介导应激反应,以及(主题B)应激和应激反应对机体状况、行为和适应性的影响。将用于假设检验的科学方法将包括在自然领域(如湖泊、河流)和生态环境(如实验池塘和溪流)环境中进行广泛的实验和比较调查。对于主题A,我们将高度依赖非致命性血液采样和电子标签。我们将通过评估硬骨鱼中主要GC皮质醇的变化来评估种群特异性的应激反应变化,并考虑栖息地质量如何影响GC反应。在一些实验中,我们将把鱼暴露在不同的保存环境中(例如,操纵热环境和流量),并评估GC的响应性。对于主题B,我们将主要在释放鱼之前使用外源性皮质醇操纵并观察GC升高的后果。在一些实验中,我们将评估压力源如何影响野生鱼类的伤口愈合,而在其他研究中,我们将重点关注繁殖成功率和生存终点。我们还将操纵环境压力源,并考虑跨季节和生活史转变的潜在延续效应。拟议的研究是新颖的,有可能对理解生态过程产生重大影响,特别是在面临环境变化的情况下。综合研究主题跨越基础-应用连续体,将提供对人为环境变化对生物体影响的功能性理解,同时阐明生理过程与种群下降之间的机制关系。例如,这项工作将揭示在新的应激源和GC反应之间是否存在不匹配。拟议的工作具有培训高素质人才的巨大空间,并将有助于确保下一代科学家了解和欣赏人类活动如何影响动物种群以及这些种群提供的生态系统服务。此外,有相当大的机会让公众和有关的利益相关者参与进来,并产生对环境管理人员有用的知识。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Cooke, Steven其他文献
Cooke, Steven的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Cooke, Steven', 18)}}的其他基金
Winter Biology of Wild Fish in a Multi-Stressor World
多重压力世界中野生鱼类的冬季生物学
- 批准号:
RGPIN-2019-06139 - 财政年份:2022
- 资助金额:
$ 5.4万 - 项目类别:
Discovery Grants Program - Individual
Evaluating the Effects of an EMF Device Intended to Mitigate Hypoxia on the Biology of Wild Fish
评估用于缓解缺氧的 EMF 装置对野生鱼类生物学的影响
- 批准号:
561435-2020 - 财政年份:2021
- 资助金额:
$ 5.4万 - 项目类别:
Alliance Grants
Generating actionable science to inform sustainable freshwater ecosystem use and shoreline development in Canada in the face of increasing human pressure
面对日益增加的人类压力,生成可行的科学知识,为加拿大的可持续淡水生态系统利用和海岸线开发提供信息
- 批准号:
570434-2021 - 财政年份:2021
- 资助金额:
$ 5.4万 - 项目类别:
Alliance Grants
Field experiment to test the effectiveness of LED lights for the behavioural guidance of imperiled American Eel during their downstream spawning migration
现场实验测试 LED 灯对濒危美洲鳗在下游产卵迁徙过程中行为引导的有效性
- 批准号:
568649-2021 - 财政年份:2021
- 资助金额:
$ 5.4万 - 项目类别:
Alliance Grants
Winter Biology of Wild Fish in a Multi-Stressor World
多重压力世界中野生鱼类的冬季生物学
- 批准号:
RGPIN-2019-06139 - 财政年份:2021
- 资助金额:
$ 5.4万 - 项目类别:
Discovery Grants Program - Individual
Developing Forensic Biomarkers for Fish Killed by Cold Shock and Impinged at Nuclear Power Plant Water Cooling Intakes
为因冷击而死亡并受到核电站水冷却入口撞击的鱼类开发法医生物标记
- 批准号:
569920-2021 - 财政年份:2021
- 资助金额:
$ 5.4万 - 项目类别:
Alliance Grants
Towards sustainable recreational fisheries in Kenauk Nature Reserve
基诺克自然保护区的可持续休闲渔业
- 批准号:
517828-2017 - 财政年份:2020
- 资助金额:
$ 5.4万 - 项目类别:
Collaborative Research and Development Grants
Supporting sustainable hydropower operation and development in British Columbia through research on fish entrainment and fish responses to gas supersaturation
通过研究鱼类夹带和鱼类对气体过饱和的反应,支持不列颠哥伦比亚省的可持续水电运营和开发
- 批准号:
474297-2014 - 财政年份:2020
- 资助金额:
$ 5.4万 - 项目类别:
Collaborative Research and Development Grants
Winter Biology of Wild Fish in a Multi-Stressor World
多重压力世界中野生鱼类的冬季生物学
- 批准号:
RGPIN-2019-06139 - 财政年份:2020
- 资助金额:
$ 5.4万 - 项目类别:
Discovery Grants Program - Individual
Fish Ecology and Conservation Physiology
鱼类生态学和保护生理学
- 批准号:
1000229160-2013 - 财政年份:2019
- 资助金额:
$ 5.4万 - 项目类别:
Canada Research Chairs
相似国自然基金
Tmem30a通过ER Stress/NF-κB信号通路调节肠上皮细胞屏障功能稳态介导炎症性肠病的研究
- 批准号:82300629
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
生理/病理应激差异化调控肝再生的“蓝斑—中缝”神经环路机制
- 批准号:82371517
- 批准年份:2023
- 资助金额:49.00 万元
- 项目类别:面上项目
槲皮素控释系统调控Mettl3/Per1修复氧化应激损伤促牙周炎骨再生及机制研究
- 批准号:82370921
- 批准年份:2023
- 资助金额:48.00 万元
- 项目类别:面上项目
Sestrin2抑制内质网应激对早产儿视网膜病变的调控作用及其机制研究
- 批准号:82371070
- 批准年份:2023
- 资助金额:49.00 万元
- 项目类别:面上项目
组蛋白乙酰化修饰ATG13激活自噬在牵张应力介导骨缝Gli1+干细胞成骨中的机制研究
- 批准号:82370988
- 批准年份:2023
- 资助金额:48.00 万元
- 项目类别:面上项目
二甲双胍抗肥胖新机制:调节小胶质细胞ER stress-EVs缓解下丘脑炎症
- 批准号:
- 批准年份:2022
- 资助金额:30 万元
- 项目类别:青年科学基金项目
肿瘤相关巨噬细胞通过Stress Granule 形成调控炎症小体促进舌鳞癌转移的机制研究
- 批准号:
- 批准年份:2021
- 资助金额:10.0 万元
- 项目类别:省市级项目
ACSL4/ER stress/GPX4通路在溃疡性结肠炎中对Ferroptosis的调控机制研究
- 批准号:
- 批准年份:2021
- 资助金额:30 万元
- 项目类别:青年科学基金项目
炎症相关因子 RKIP 通过活化 ER stress 相关的IRE1α/XBP1 信号轴调控肝脏疾病的机制研究
- 批准号:LY22H030007
- 批准年份:2021
- 资助金额:0.0 万元
- 项目类别:省市级项目
NRF2/MFN2/ERS信号异常促进ADSCs衰老和肥大型肥胖皮下脂肪组织胰岛素抵抗的机制研究
- 批准号:32000511
- 批准年份:2020
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Assessing adaptive and maladaptive stress responses in wild Capuchin monkeys
评估野生卷尾猴的适应性和适应不良应激反应
- 批准号:
2341358 - 财政年份:2024
- 资助金额:
$ 5.4万 - 项目类别:
Standard Grant
Redox stress resilience in aging skeletal muscle
衰老骨骼肌的氧化还原应激恢复能力
- 批准号:
10722970 - 财政年份:2023
- 资助金额:
$ 5.4万 - 项目类别:
Platelet Metabolic Stress Induces Thrombo-Inflammation to Drive Endothelial Dysfunction in PH
PH 中血小板代谢应激诱导血栓炎症导致内皮功能障碍
- 批准号:
10736724 - 财政年份:2023
- 资助金额:
$ 5.4万 - 项目类别:
Regulation of wound healing pathways by NLRP10 in cutaneous Leishmaniasis
NLRP10 对皮肤利什曼病伤口愈合途径的调节
- 批准号:
10783649 - 财政年份:2023
- 资助金额:
$ 5.4万 - 项目类别:
Regulation of Schwann Cell Mitochondria Homeostasis in Painful Peripheral Neuropathy
疼痛性周围神经病中雪旺细胞线粒体稳态的调节
- 批准号:
10790951 - 财政年份:2023
- 资助金额:
$ 5.4万 - 项目类别:
Endogenous retrovirus in joint aging and osteoarthritis development
内源性逆转录病毒在关节衰老和骨关节炎发展中的作用
- 批准号:
10719364 - 财政年份:2023
- 资助金额:
$ 5.4万 - 项目类别:
Role of RNA helicase Ddx5 in pathological cardiac remodeling
RNA解旋酶Ddx5在病理性心脏重塑中的作用
- 批准号:
10718560 - 财政年份:2023
- 资助金额:
$ 5.4万 - 项目类别:
Cholesterol homeostasis in the vertebrate retina
脊椎动物视网膜中的胆固醇稳态
- 批准号:
10580969 - 财政年份:2023
- 资助金额:
$ 5.4万 - 项目类别:
Role of novel RNA binding protein LARP6 in alcoholic cardiomyopathy
新型RNA结合蛋白LARP6在酒精性心肌病中的作用
- 批准号:
10593688 - 财政年份:2023
- 资助金额:
$ 5.4万 - 项目类别:
Therapeutic targeting of FKBP51 for the prevention of stress-induced preterm birth
FKBP51 预防应激性早产的治疗靶点
- 批准号:
10758367 - 财政年份:2023
- 资助金额:
$ 5.4万 - 项目类别: