Structure, self-assembly properties and mechanism of action of antimicrobial peptides, amyloid peptides and silk proteins

抗菌肽、淀粉样肽和丝蛋白的结构、自组装特性和作用机制

• 批准号: RGPIN-2015-04721
• 负责人: Auger, Michèle
• 金额: $ 4.3万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632506
• 关键词: Structure; self; assembly; properties; mechanism

Our research program focuses on the determination of the structure, self-assembly properties and mechanism of action of several peptides and proteins of biomedical interest. We will focus on antibiotic resistance and neurodegenerative diseases that rely on the structure and assembly of peptides/proteins. We will also study the natural and synthetic production of silk to help in developing biomaterials, especially implants and scaffolds for tissue regeneration. These systems will be investigated by a combination of novel solid-state nuclear magnetic resonance approaches and complementary information will be obtained by several other biophysical techniques.

我们的研究重点是几种生物医学感兴趣的多肽和蛋白质的结构、自组装特性和作用机制的确定。我们将专注于抗生素耐药性和依赖于多肽/蛋白质的结构和组装的神经退行性疾病。我们还将研究天然和人工合成蚕丝的生产，以帮助开发生物材料，特别是用于组织再生的植入物和支架。这些系统将通过结合新的固态核磁共振方法进行研究，并将通过其他几种生物物理技术获得补充信息。