In vitro biomimetic microfluidic models for toxicology studies

用于毒理学研究的体外仿生微流体模型

• 批准号: RGPIN-2017-04844
• 负责人: Elvira, Katherine
• 金额: $ 1.6万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632585
• 关键词: vitro; biomimetic; microfluidic; models; toxicology

Lipid bilayers are complex and ubiquitous entities that regulate fundamental processes within cellular environments. In particular, the complexity of lipid bilayers and how they mediate the transport of drugs and molecules into cells is an essential unsolved problem in biology, which has damaging ramifications for drug discovery.

脂质双分子层是复杂的和普遍存在的实体，调节细胞环境中的基本过程。特别是，脂质双层的复杂性以及它们如何介导药物和分子转运到细胞中是生物学中一个基本的未解决的问题，这对药物发现具有破坏性影响。