Heterocycles in natural products: Enzymes, pathways, and chemistry

天然产物中的杂环：酶、途径和化学

• 批准号: RGPIN-2016-03778
• 负责人: Ryan, Katherine
• 金额: $ 3.35万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632747
• 关键词: Heterocycles; natural; products; Enzymes; pathways

Molecules isolated from living organisms are some of the most chemically complex and medicinally relevant compounds ever isolated. These natural product molecules play critical roles as antibiotics and other drugs. My research group is interested in understanding how nature constructs natural products, and our long-term goal is to harness this knowledge to develop new molecules and to understand how novel enzymes function. In this program, we will use indolmycin, a unique antibiotic, with translational potential as an agent against methicillin-resistant

从活的生物体中分离的分子是有史以来分离的化学上最复杂和医学上最相关的化合物。这些天然产物分子作为抗生素和其他药物发挥着关键作用。我的研究小组对了解自然界如何构建天然产物感兴趣，我们的长期目标是利用这些知识开发新分子，并了解新酶的功能。在该计划中，我们将使用吲哚霉素，这是一种独特的抗生素，具有转化潜力，作为对抗甲氧西林耐药的药物