Metal mediated and catalyzed organic synthetic methods

金属介导和催化的有机合成方法

• 批准号: 156609-2011
• 负责人: Green, James
• 金额: $ 2.55万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=569508
• 关键词: Metal; mediated; catalyzed; organic; synthetic

The objective of the proposed research is to develop and understand a series of novel organic chemical reactions mediated by transition metal complexes or catalyzed by either transition metal complexes or main group compounds. The goals include the development of types of carbon-carbon bond forming reactions not normally readily accomplished by traditional organic chemical processes (i.e., the pattern of reactivity is inverted relative to most organic compounds), and to prepare and use compounds that could not normally exist if it were not for the presence of the metal unit. In particular the proposed indium, rhodium, and iridium catalyzed allylation reactions, in conjunction with other catalytic reactions, are designed for being catalytic methods of giving this inverted pattern of reactivity. The proposed alkynedicobalt complexes are designed to make possible the use of compounds that could not be isolated if not for the cobalt. The ultimate goal for the reactions investigated is to develop the chemistry to the point where it can be used in the synthesis of organic molecules of importance, such as compounds that have potential anti-cancer properties, antileukemic properties, antibacterial or insect antifeedant activity. In many cases, the organic compounds simply have interesting structures, and in other cases the prepared compounds are designed to address fundamental questions, such as what makes a compound stable (or unstable).

该研究的目的是开发和理解一系列由过渡金属配合物介导或由过渡金属配合物或主族化合物催化的新型有机化学反应。这些目标包括开发通常不容易通过传统有机化学方法完成的碳-碳键形成反应的类型（即，反应性模式相对于大多数有机化合物是相反的），以及制备和使用如果没有金属单元的存在通常不能存在的化合物。特别地，所提出的铟、铑和铱催化的烯丙基化反应与其它催化反应结合，被设计为提供这种反向反应性模式的催化方法。所提出的炔二钴配合物的设计，使可能使用的化合物，不能被分离，如果没有钴。 研究反应的最终目标是将化学发展到可以用于合成重要有机分子的程度，例如具有潜在抗癌特性，抗白血病特性，抗菌或昆虫拒食活性的化合物。在许多情况下，有机化合物只是具有有趣的结构，而在其他情况下，所制备的化合物旨在解决基本问题，例如是什么使化合物稳定（或不稳定）。