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Bioorganic Methodology to Create Novel Biomolecular Platforms to Address Critical Needs in Molecular Recognition and Function

生物有机方法论创建新型生物分子平台，以满足分子识别和功能的关键需求

基本信息

批准号：
RGPIN-2017-05232
负责人：
Honek, John
金额：
$ 4.37万
依托单位：
University of Waterloo
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2017
资助国家：
加拿大
起止时间：
2017-01-01 至 2018-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632845
关键词：
Bioorganic Methodology Create Novel Biomolecular

项目摘要

This research program focuses on the creation of novel biomolecular scaffolds that will become key elements in the chemical design of selective affinity receptors for small organic and inorganic molecules as well as unique molecular frameworks useful in controlling macromolecule interactions with chemical surfaces and advanced materials. The creation of innovative molecular recognition systems is a critical enabling technology that underpins the development of new materials and therapeutic agents for society. Chemical and biochemical manipulation of complex multisubunit proteins and viruses will be undertaken to serve as unique, self-assembling biomolecular platforms valuable for materials and biomaterials science. Currently intense interest is being directed toward the application of large multisubunit proteins and viruses to the synthesis of molecular scaffolds able to "hang and orient" photovoltaic systems, or to serve as building blocks for the fabrication of biomolecular batteries, novel biofibers or drug delivery systems. Hence there is exceptional need for developing the chemistry of these complex structures and to train the next generation of scientists to contribute to the application of renewable biosystems to materials science, energy systems and therapeutics. Various levels of biomolecular complexity will be explored by these chemical approaches. These include:

这个研究项目的重点是创造新的生物分子支架，这将成为小有机和无机分子的选择性亲和受体的化学设计的关键要素，以及在控制与化学表面和先进材料的大分子相互作用方面有用的独特分子框架。创新分子识别系统的创建是一项关键的使能技术，它支撑着社会新材料和治疗剂的发展。复杂的多亚基蛋白质和病毒的化学和生化操作将作为独特的，自组装的生物分子平台，对材料和生物材料科学有价值。目前，人们对将大型多亚基蛋白和病毒应用于合成能够“悬挂和定向”光伏系统的分子支架，或作为制造生物分子电池、新型生物纤维或药物输送系统的基础材料有着浓厚的兴趣。因此，发展这些复杂结构的化学和培养下一代科学家为可再生生物系统在材料科学、能源系统和治疗学中的应用做出贡献是非常必要的。不同层次的生物分子复杂性将通过这些化学方法来探索。这些包括: