Probes for imaging enzyme activity

酶活性成像探针

• 批准号: RGPIN-2016-06593
• 负责人: Phenix, Christopher
• 金额: $ 2.19万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632865
• 关键词: Probes; imaging; enzyme; activity

The spread of cancer from a primary tumor to a distant location, a process termed metastasis, is the cause of death in 90% of patients. A critical step in the progression of cancer is the remodeling of the local environment with which tumours begin to invade. This remodeling is thought to occur primarily through molecular machines called proteases, enzymes that digest the tumour environment providing a permissive space for cancer cells to invade. However, the exact mechanisms and the specific proteases that help cancers spread are not well understood. We propose to design and develop new chemical agents that can reveal the activity of specific proteases operating in the tumour and the tumour environment using positron emission tomography (PET).

癌症从原发肿瘤扩散到远处，这一过程称为转移，是90%患者死亡的原因。癌症进展的关键步骤是局部环境的重塑，肿瘤开始以该局部环境侵入。这种重塑被认为主要是通过称为蛋白酶的分子机器发生的，这些酶消化肿瘤环境，为癌细胞入侵提供允许的空间。然而，帮助癌症扩散的确切机制和特定蛋白酶还不清楚。我们建议设计和开发新的化学试剂，可以揭示在肿瘤和肿瘤环境中使用正电子发射断层扫描（PET）的特定蛋白酶的活性。