Spatiotemporal resolution of the contributions of pre- and post-synaptic mechanisms to synapse-specific transmission variability and synaptic plasticity

突触前和突触后机制对突触特异性传递变异性和突触可塑性的贡献的时空分辨率

• 批准号: 375924
• 负责人: Getz Angela M
• 金额: $ 10.93万
• 依托单位: Universit de Bordeaux I (France)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-11-01 至 2020-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=375924&lang=en
• 关键词: Bio-Sensors; Glutamate Receptor Trafficking; High Resolution Imaging; Learning And Memory; Molecular And Cellular Neuroscience; Neuroplasticity; Synaptic Plasicity; Synaptic Transmission; Synaptic Vesicle Release

Activity-dependent changes of synaptic efficacy are the cellular basis of learning and memory. Synaptic plasticity bidirectionally modifies synaptic strength by enhancing or depressing transmission, effected through a complexity of mechanisms that act pre

突触效能的活动依赖性变化是学习和记忆的细胞基础。突触可塑性通过增强或抑制传递来双向改变突触强度，这是通过一系列复杂的机制来实现的，