Activity-dependent regulation of glutamate receptor trafficking in neurons

神经元中谷氨酸受体运输的活动依赖性调节

• 批准号: DE170100546
• 负责人: Dr Tong Wang
• 金额: $ 26.03万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE170100546
• 关键词: Activity; dependent; regulation; glutamate; receptor

This proposal aims to understand the molecular mechanisms of neuronal communication and how neurons modify their synaptic strength. Although these processes are essential for normal brain function, the precise underlying mechanisms are not well understood. This project will use structural, biochemical, molecular and cell biological assays to study the molecular processes that control glutamate receptor trafficking in the postsynaptic compartment. It will elucidate how neural plasticity is generated and maintained, information critical for understanding sensory processing, learning and memory throughout life. The findings could identify cellular targets for interventions to enhance cognitive performance and maintain optimal brain function.

该提案旨在了解神经元通讯的分子机制以及神经元如何改变其突触强度。尽管这些过程对于正常的大脑功能至关重要，但其确切的潜在机制尚不清楚。该项目将使用结构、生化、分子和细胞生物学测定来研究控制突触后区室中谷氨酸受体运输的分子过程。它将阐明神经可塑性是如何产生和维持的，这些信息对于理解一生中的感觉处理、学习和记忆至关重要。这些发现可以确定干预措施的细胞目标，以增强认知能力并维持最佳的大脑功能。