Non-mechanical continuous flow micropumps for biomedical applications

用于生物医学应用的非机械连续流微型泵

• 批准号: 386864-2012
• 负责人: Dalton, Colin
• 金额: $ 1.53万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=637100
• 关键词: Non; mechanical; continuous; flow; micropumps

This research will focus on investigating non-mechanical micropumping methods for making small devices to pump fluid in bio-medical devices. The fluid will be pumped using electricity through small microneedles. The chosen area of research is specifically aimed at improving patient care by removing the need for hypodermic syringes and providing the path into automated drug delivery methods. Specifically, AC electrokinetic techniques will be investigated for pumping fluids through custom made silicon microneedle arrays. Microneedle arrays penetrate the upper part of skin, avoiding the nerves, allowing for practically painless skin penetration. The investigation will focus on the need to create small, low power, reliable devices. Traditional methods of fabricating the devices will be used initially, such as photolithography, coupled with computer simulations to design optimal devices. During the later stages of the research, fabrication will transition to alternate technologies, such as commercial silicon chip manufacturing processes and laser micromachining. To achieve these goals, a series of experimental testing, simulation and design optimization of AC electrokinetic micropumps will be conducted. The experimental data will be compared with simulation data and the simulation models modified accordingly, iteratively leading to new designs of micropumps. The research methodology will involve investigating several electrokinetic micropumping factors, such as voltages and currents applied; temperature issues such as damage to the fluid solution, fluid properties within microfluidic channels and also the geometry of the electrode arrays and the microfludics channels themselves. These devices will form an integral part of a biomedical engineering solution for healthcare.

这项研究将集中于研究非机械微泵方法，以制造用于生物医疗装置中的液体泵的小型装置。这种液体将通过微小的微针用电力泵送。选定的研究领域专门旨在通过消除对皮下注射器的需求并提供进入自动给药方法的途径来改善患者护理。具体地说，将研究通过定制的硅微针阵列泵送流体的交流电动技术。微针阵列穿透皮肤的上部，避开神经，允许几乎无痛的皮肤穿透。调查的重点将是制造小型、低功耗、可靠设备的需求。制造器件的传统方法最初将被使用，例如光刻，结合计算机模拟来设计最佳器件。在研究的后期阶段，制造将过渡到替代技术，如商业硅片制造工艺和激光微加工。为了实现这些目标，将对交流电动微泵进行一系列的实验测试、仿真和设计优化。将实验数据与仿真数据进行比较，并对仿真模型进行相应的修改，迭代地产生新的微泵设计。研究方法将包括调查几个电动微泵因素，如施加的电压和电流；温度问题，如对流体溶液的损害，微流控通道内的流体性质，以及电极阵列和微流控通道本身的几何形状。这些设备将构成医疗保健生物医学工程解决方案的组成部分。